Evidence map›Paper›PMID 39143757›Full record

ArticleAnalytical chemistry2024

Automated Immunoprecipitation, Sample Preparation, and Individual Ion Mass Spectrometry Platform for Proteoforms.

Benjamin J Des Soye, John P McGee, Michael A R Hollas, Eleonora Forte, Ryan T Fellers, Rafael D Melani, John T Wilkins, Philip D Compton, Jared O Kafader, Neil L Kelleher

Abstract read
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The Proteoform Landscape of Tau from the Human Brain.Journal of proteome research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin J Des SoyeDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-5480-4192
John P McGeeDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.
Michael A R HollasDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-0797-3134
Eleonora ForteProteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-6095-2797
Ryan T FellersDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.
Rafael D MelaniDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.
John T WilkinsDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-8781-1329
Philip D ComptonIntegrated Protein Technologies, San Jose, California 95134, United States.
Jared O KafaderDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-5359-264X
Neil L KelleherDepartments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-8815-3372

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometerS10OD025194 · OD · NORTHWESTERN UNIVERSITY · PI COMPTON, PHILIP DANIEL · 2018 to 2018
$795k
NCI NIH HHS P30 CA060553NIGMS NIH HHS P41 GM108569NIH HHS S10 OD025194
6 · The paper itself

Abstract

Charge detection mass spectrometry (CDMS) is a well-established technique that provides direct mass spectral outputs regardless of analyte heterogeneity or molecular weight. Over the past few years, it has been demonstrated that CDMS can be multiplexed on Orbitrap analyzers utilizing an integrated approach termed individual ion mass spectrometry (I

Identifiers

PMID39143757
PMCPMC11825902

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.