Evidence map›Paper›PMID 39143534›Full record

ArticleBMC pregnancy and childbirth2024

Pre-pregnancy overweight or obesity moderates the association between prenatal maternal depressive symptoms and infant cord blood omega-3 levels.

Lauren A Costello, Katherine Ziegler, Lacey McCormack, Anahid Akbaryan, Julianna Collazo Vargas, William S Harris, Kristina H Jackson, Maria Barber, Santiago Morales, Amy J Elliott and 2 more

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In one paragraph

Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lauren A CostelloDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, One Park Avenue, 8th Floor, New York, NY, 10016, USA. Lauren.Costello@nyulangone.org.
Katherine ZieglerAvera Research Institute, Sioux Falls, SD, 57108, USA.
Lacey McCormackAvera Research Institute, Sioux Falls, SD, 57108, USA.
Anahid AkbaryanDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, One Park Avenue, 8th Floor, New York, NY, 10016, USA.
Julianna Collazo VargasDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, One Park Avenue, 8th Floor, New York, NY, 10016, USA.
William S HarrisDepartment of Internal Medicine, University of South Dakota School of Medicine, Sioux Falls, SD, 57108, USA.
Kristina H JacksonFatty Acid Research Institute, Sioux Falls, SD, 57106, USA.
Maria BarberAvera Research Institute, Sioux Falls, SD, 57108, USA.
Santiago MoralesDepartment of Psychology, University of Southern California, Los Angeles, CA, 90007, USA.
Amy J ElliottAvera Research Institute, Sioux Falls, SD, 57108, USA.
Christine Hockett *Avera Research Institute, Sioux Falls, SD, 57108, USA.
Lauren C Shuffrey *Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, One Park Avenue, 8th Floor, New York, NY, 10016, USA.

Funding

Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7M
NIH HHS UH3 OD023279ODCDC CDC HHS UH3 OD023279
6 · The paper itself

Abstract

backgroundEmpirical evidence has demonstrated associations between pre-pregnancy obesity and perinatal maternal depressive symptoms. Omega-3 is an essential fatty acid derived from dietary sources that is critical for fetal brain development. Pre-pregnancy obesity is associated with higher omega-3 intake, but a weaker association between dietary intake and respective maternal and cord blood omega-3 levels. Further, lower intake of omega-3 during pregnancy has been linked to higher depressive symptoms. Yet, prior studies have not examined the interactive effects of pre-pregnancy overweight or obesity (OWOB) and prenatal maternal mental health symptoms on infant cord blood omega-3 levels.

methodsParticipants included 394 maternal-infant dyads from the NIH Environmental influences on Child Health Outcomes (ECHO) - Safe Passage Study in South Dakota. A pre-pregnancy body mass index (BMI) > 25 was used to dichotomize participants as OWOB (54%) vs. non-OWOB (46%). Prenatal maternal depressive symptoms were measured using the Edinburgh Postnatal Depression Scale (EPDS) and prenatal maternal anxiety symptoms were measured using the State-Trait Anxiety Inventory (STAI). We implemented linear regression models to examine the interaction term between pre-pregnancy BMI category and prenatal maternal mental health symptoms on cord blood omega-3 levels. Secondary analyses were stratified by pre-pregnancy BMI category.

resultsWe observed a significant interaction between pre-pregnancy BMI category and prenatal maternal depressive symptoms with cord blood omega-3 (F(4,379) = 6.21, p < .0001, adj. R

conclusionsFindings suggest maternal-placental transfer of omega-3 may represent one pathway by which maternal metabolic and mental health impacts infant development.

Indexed as

DepressionFatty Acids, Omega-3Fetal BloodPregnancy ComplicationsAdultBody Mass IndexFemaleHumansInfant, NewbornMaleObesityOverweightPregnancyYoung AdultFatty Acids, Omega-3Infant cord bloodMaternal BMIMaternal mental healthOmega-3Perinatal depression

Identifiers

PMID39143534
PMCPMC11323614

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.