Evidence map›Paper›PMID 39143473›Full record

ArticleBMC public health2024

The association between dental caries and serum crp in the us adult population: evidence from NHANES 2015-2018.

Abdullah AlShammari, Saleh AlSaleh, Abdulaziz AlKandari, Sara AlSaqabi, Dalal AlJalahmah, Woroud AlSulimmani, Muath AlDosari, Hesham AlHazmi, Hend AlQaderi

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Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdullah AlShammariMinistry of Health Kuwait, Jamal Abdel Nasser Street, Sulaibikhat, 13001, Kuwait. Drabdullash@gmail.com.
Saleh AlSalehMinistry of Health Kuwait, Jamal Abdel Nasser Street, Sulaibikhat, 13001, Kuwait.
Abdulaziz AlKandariMinistry of Health Kuwait, Jamal Abdel Nasser Street, Sulaibikhat, 13001, Kuwait.
Sara AlSaqabiMinistry of Health Kuwait, Jamal Abdel Nasser Street, Sulaibikhat, 13001, Kuwait.
Dalal AlJalahmahMinistry of Health Kuwait, Jamal Abdel Nasser Street, Sulaibikhat, 13001, Kuwait.
Woroud AlSulimmaniMinistry of Health Kuwait, Jamal Abdel Nasser Street, Sulaibikhat, 13001, Kuwait.
Muath AlDosariCollege of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Hesham AlHazmiHarvard School of Dental Medicine, Boston, MA, USA.
Hend AlQaderiTufts University School of Dental Medicine, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDental caries remains one of the most prevalent diseases worldwide, affecting 29.4% of the global population. Despite numerous efforts to diagnose, predict, and prevent dental caries, the incidence continues to rise. Salivary biomarkers provide a non-invasive means for early detection of various oral conditions. C-reactive protein (CRP) is a key marker, elevated in both oral and general inflammatory conditions such as diabetes, periodontitis and oral squamous cell carcinoma. Considering the emerging connection between oral and systemic health, it is worth exploring the various factors associated with this widespread disease. This study investigates the association between CRP levels and dental caries in the United States population, utilizing data from the National Health and Nutrition Examination Survey (NHANES).

methodsThe study analyzed data from the 2015-2018 NHANES cycles, focusing on a nationally representative sample of individuals aged 30 years and above. Weighted multivariable negative binomial and logistic regression analyses were employed to explore the relationship between dental caries and CRP levels, adjusting for age, gender, race, education level, diabetes status, and gum disease.

resultsThe results of the negative binomial regression analysis demonstrated a positive association between higher CRP levels and an increased mean number of dental caries (Adjusted Mean Ratio [AMR] = 1.7; 95% CI: 1.3 - 2; P: < 0.001). The logistic regression analysis showed that individuals with higher CRP levels have a 50% increase in the odds of developing dental caries (AOR: 1.5, CI: 1.2 - 1.9; P: < 0.01).

conclusionThe results of this cross-sectional study of the U.S. population highlight the positive association between high CRP levels and increased dental caries. These findings contribute to the growing body of evidence supporting the integration of oral and systemic health care. Further research is necessary to deepen our understanding of the mechanistic relationship between CRP levels and dental caries.

Indexed as

C-Reactive ProteinDental CariesNutrition SurveysAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedUnited StatesBiomarkersC-Reactive ProteinC-Reactive Protein (CRP)Cross-sectional studyDental CariesDental epidemiologyOral microbiomeSalivary biomarkers

Identifiers

PMID39143473
PMCPMC11323639

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.