Evidence map›Paper›PMID 39143449›Full record

ArticleMolecular neurobiology2025

Dose-Dependent Attenuation of the Efficacy of Clitoria ternatea by Cobalt Oxide Nanoparticles Against Diabetes-Induced Cognitive Impairment.

Bibhanwita Satpathy, Nishigandha Sa, Anindita Behera, Pratap Kumar Sahu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. 5,7,4'-Trimethoxyflavone Attenuates Cognitive Impairment in Diabetic Mice via Inhibition of NLRP3 Inflammasome Activation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bibhanwita SatpathySchool of Pharmaceutical Sciences, Siksha ' O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha, India.
Nishigandha SaSchool of Pharmaceutical Sciences, Siksha ' O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha, India.
Anindita BeheraCollege of Pharmaceutical Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bengaluru, Karnataka, 560078, India. anindita-sps@dsu.edu.in.ORCID http://orcid.org/0000-0002-2990-0956
Pratap Kumar SahuSchool of Pharmaceutical Sciences, Siksha ' O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a metabolic disorder caused by insulin deficiency, insulin resistance, genetic alterations, and oxidative stress. The high glucose levels may impair the functioning of nerve cells, leading to neurodegenerative diseases, including cognitive impairment. Clitoria ternatea has various pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic, and neuroprotective effects. The present study evaluates the efficacy of fresh flower aqueous extract of Clitoria ternatea against diabetes-induced cognitive impairment. The challenges in delivering drugs targeting the brain possess the limitations of crossing the blood-brain barrier. Metal nanoparticles are considered the most reliable brain drug delivery systems. Considering the neurotoxicity of cobalt oxide, whether it can be used to improve brain delivery is also evaluated. Cobalt oxide nanoparticles (Co

Indexed as

ClitoriaCobaltCognitive DysfunctionDiabetes Mellitus, ExperimentalMetal NanoparticlesNanoparticlesOxidesPlant ExtractsAnimalsAntioxidantsBrainDose-Response Relationship, DrugMaleNeuroprotective AgentsOxidative StressRatsAntioxidantsCobaltcobalt oxideNeuroprotective AgentsOxidesPlant ExtractsClitoria ternateaCobalt oxide nanoparticlesCognitive deficitDiabetesNeurotoxicityStreptozotocin

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.