Evidence map›Paper›PMID 39143423›Full record

ArticleBritish journal of haematology2024

Genome-wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia.

Qianqian Zhu, Ram Nambiar, Emily Schultz, Xinyu Gao, Shuyi Liang, Yael Flamand, Kristen Stevenson, Peter D Cole, Lisa Gennarini, Marian H Harris and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qianqian ZhuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID https://orcid.org/0000-0003-2516-6675
Ram NambiarDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Emily SchultzDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Xinyu GaoDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Shuyi LiangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID https://orcid.org/0009-0001-8776-2125
Yael FlamandDepartment of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Kristen StevensonDepartment of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Peter D ColeDivision of Pediatric Hematology/Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Lisa GennariniDivision of Pediatric Hematology, Oncology and Cellular Therapy, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA.
Marian H HarrisDepartment of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA.
Justine M KahnDivision of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Irving Medical Center, New York, New York, USA.
Elena J LadasDivision of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Irving Medical Center, New York, New York, USA.
Uma H AthaleDivision of Pediatric Hematology/Oncology, McMaster University, Hamilton, Ontario, Canada.
Thai Hoa TranDivision of Pediatric Hematology and Oncology, Charles-Bruneau Cancer Center, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Bruno MichonDivision of Hematology-Oncology, Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada.
Jennifer J G WelchDivision of Pediatric Hematology-Oncology, Hasbro Children's Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Stephen E SallanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, Massachusetts, USA.
Lewis B SilvermanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, Massachusetts, USA.
Kara M KellyDepartment of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID https://orcid.org/0000-0003-1473-3937
Song YaoDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
Genetic underpinnings of ethnic disparities in bone toxicities between Hispanic and non-Hispanic children treated for acute lymphoblastic leukemiaR03CA223730 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI KELLY, KARA M, YAO, SONG · 2018 to 2019
$174k
NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA16056NCI NIH HHS R03 CA223730NIH HHS R03 CA223730Rally Foundation Independent Investigator AwardRoswell Park Alliance Foundation
6 · The paper itself

Abstract

Bone toxicities are common among paediatric patients treated for acute lymphoblastic leukaemia (ALL) with potentially major negative impact on patients' quality of life. To identify the underlying genetic contributors, we conducted a genome-wide association study (GWAS) and a transcriptome-wide association study (TWAS) in 260 patients of European-descent from the DFCI 05-001 ALL trial, with validation in 101 patients of European-descent from the DFCI 11-001 ALL trial. We identified a significant association between rs844882 on chromosome 20 and bone toxicities in the DFCI 05-001 trial (p = 1.7 × 10

Indexed as

Genome-Wide Association StudyPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentChildChild, PreschoolFemaleFractures, BoneHumansMalePolymorphism, Single NucleotideQuantitative Trait Lociacute lymphoblastic leukemiabone toxicitiesCLINICAL TRIALSgenome‐wide association study

Identifiers

PMID39143423
PMCPMC11568943

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.