Evidence map›Paper›PMID 39143350›Full record

Observational studyAngiogenesis2024

Maternal serum PlGF associates with 3D power doppler ultrasound markers of utero-placental vascular development in the first trimester: the rotterdam periconception cohort.

Eline S de Vos, A H Jan Danser, Anton H J Koning, Sten P Willemsen, Lotte E van der Meeren, Eric A P Steegers, Régine P M Steegers-Theunissen, Annemarie G M G J Mulders

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Angiogenesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eline S de VosDepartment of Obstetrics and Gynecology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.ORCID 0000-0002-6933-3204
A H Jan DanserDepartment of Pharmacology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Anton H J KoningDepartment of Pathology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.ORCID 0000-0002-3147-0887
Sten P WillemsenDepartment of Obstetrics and Gynecology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.ORCID 0000-0002-1675-2931
Lotte E van der MeerenDepartment of Pathology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.ORCID 0000-0002-4537-5645
Eric A P SteegersDepartment of Obstetrics and Gynecology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.ORCID 0000-0001-6658-9274
Régine P M Steegers-TheunissenDepartment of Obstetrics and Gynecology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.ORCID 0000-0002-4353-5756
Annemarie G M G J MuldersDepartment of Obstetrics and Gynecology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. a.mulders@erasmusmc.nl.ORCID 0000-0002-4407-8323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE (S): Circulating angiogenic factors are used for prediction of placenta-related complications, but their associations with first-trimester placental development is unknown. This study investigates associations between maternal angiogenic factors and utero-placental vascular volume (uPVV) and utero-placental vascular skeleton (uPVS) as novel imaging markers of volumetric and morphologic (branching) development of the first-trimester utero-placental vasculature.

methodsIn 185 ongoing pregnancies from the VIRTUAL Placenta study, a subcohort of the ongoing prospective Rotterdam Periconception cohort, three-dimensional power Doppler ultrasounds of the placenta were obtained at 7-9-11 weeks gestational age (GA). The uPVV was measured as a parameter of volumetric development and reported the vascular quantity in cm

resultsSerum PlGF was positively associated with uPVV and uPVS development (uPVV: β = 0.39, 95% CI = 0.15;0.64; bifurcation points: β = 4.64, 95% CI = 0.04;9.25; crossing points: β = 4.01, 95% CI = 0.65;7.37; total vascular length: β = 13.33, 95% CI = 3.09;23.58, all p-values < 0.05). sEng/PlGF ratio was negatively associated with uPVV and uPVS development. We observed no associations between sFlt-1, sEng or sFlt-1/PlGF ratio and uPVV and uPVS development. CONCLUSION(S): Higher first-trimester maternal serum PlGF concentration is associated with increased first-trimester utero-placental vascular development as reflected by uPVV and uPVS. Clinical trial registration number Dutch Trial Register NTR6854.

Indexed as

BiomarkersPlacentaPlacenta Growth FactorPregnancy Trimester, FirstAdultCohort StudiesFemaleHumansImaging, Three-DimensionalPlacentationPregnancyProspective StudiesUltrasonography, DopplerUltrasonography, PrenatalUterusVascular Endothelial Growth Factor Receptor-1BiomarkersPGF protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1AngiogenesisAngiogenic factorsPlacentaPreeclampsiasFlt-1Spiral artery remodeling

Identifiers

PMID39143350
PMCPMC11564232

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.