Evidence map›Paper›PMID 39143333›Full record

Observational studyArchives of gynecology and obstetrics2024

Endometriosis of the appendix: prevalence, associated lesions, and proposal of pathogenetic hypotheses. A retrospective cohort study with prospectively collected data.

Gabriele Centini, Alessandro Ginetti, Irene Colombi, Alberto Cannoni, Matteo Giorgi, Helder Ferreira, Francesco Fedele, Martina Pacifici, Francesco Giuseppe Martire, Errico Zupi and 1 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Appendicitis with Appendicular Phlegmon Secondary to Endometriosis.Sultan Qaboos University medical journal · 2025
    Article
  7. Metabolomics for the identification of biomarkers in endometriosis.Archives of gynecology and obstetrics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gabriele CentiniDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.
Alessandro GinettiDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.
Irene ColombiDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.
Alberto CannoniDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.
Matteo GiorgiDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.
Helder FerreiraMinimally Invasive Gynecological Surgery Unit of Centro Hospitalar Universitário do Porto, Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto, Porto, Portugal.
Francesco FedeleDepartment of Obstetrics and Gynecology, Fondazione "Policlinico-Mangiagalli-Regina Elena" University of Milan, Milan, Italy.
Martina PacificiDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.
Francesco Giuseppe MartireDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.
Errico ZupiDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy. errico.zupi@unisi.it.ORCID http://orcid.org/0000-0003-0735-6301
Lucia LazzeriDepartment of Molecular and Developmental Medicine, Obstetrics and Gynaecology, University of Siena, Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the prevalence of endometriosis of the appendix and the association with other pelvic localizations of the disease and to provide pathogenesis hypotheses.

methodsMonocentric, observational, retrospective, cohort study. Patients undergoing laparoscopic endometriosis surgery in our tertiary referral center were consecutively enrolled. The prevalence of the different localizations of pelvic endometriosis including appendix involvement detected during surgery was collected. Included patients were divided into two groups based on the presence of appendiceal endometriosis. Women with a history of appendectomy were excluded. MEASUREMENTS AND MAIN

resultsFour hundred-sixty patients were included for data analysis. The prevalence of appendiceal endometriosis was 2.8%. In patients affected by endometriosis of the appendix, concomitant ovarian and/or bladder endometriosis were more frequently encountered, with prevalence of 53.9% (vs 21.0% in non-appendiceal endometriosis group, p = 0.005) and 38.4% (vs 11.4%, p = 0.003), respectively. Isolated ovarian endometriosis was significantly associated to appendiceal disease compared to isolated uterosacral ligament (USL) endometriosis or USL and ovarian endometriosis combined (46.2% vs 15.4% vs 7.7%, p < 0.001). Poisson regression analysis revealed a 4.1-fold and 4.4-fold higher risk of ovarian and bladder endometriosis, respectively, and a 0.1-fold risk of concomitant USL endometriosis in patients with appendiceal involvement.

conclusionInvolvement of the appendix is not uncommon among patients undergoing endometriosis surgery. Significant association was detected between appendiceal, ovarian, and bladder endometriosis that may be explained by disease dissemination coming from endometrioma fluid shedding. Given the prevalence of appendiceal involvement, counseling regarding the potential need for appendectomy during endometriosis surgery should be considered.

Indexed as

AppendixEndometriosisAdultCecal DiseasesCohort StudiesFemaleHumansLaparoscopyMiddle AgedOvarian DiseasesPrevalenceRetrospective StudiesUrinary Bladder DiseasesAppendectomyAppendiceal endometriosisBladder endometriosisDeep infiltrating endometriosisOvarian endometriosis

Identifiers

PMID39143333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.