ArticleNature2024
The genomic basis of childhood T-lineage acute lymphoblastic leukaemia.
Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06855810 (Chinese Children's Cancer Group T-cell Acute Lymphoblastic Leukemia -2025 Project), which is not on this map. Cited by 98 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06855810 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation
Chinese Children's Cancer Group T-cell Acute Lymphoblastic Leukemia -2025 Project
Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nelarabine in T-cell acute lymphoblastic leukemia: intracellular metabolism and molecular mode-of-action.Leukemia · 2025Pooled it
- Phase I/II Study of the CDK2/9 Inhibitor Fadraciclib in Combination with Chemotherapy in Children with Advanced Malignancies: Arm K of the AcSé-ESMART Trial.Targeted oncology · 2026Trial
- PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia.EMBO molecular medicine · 2026Article
- Understanding and clinical approach to early T-cell precursor acute lymphoblastic leukemia.Blood research · 2026Review
- Article
- Clonal selection of somatic mutations shapes NK cell memory.bioRxiv : the preprint server for biology · 2026Article
- Histiocytosis development and clinical variation through the lens of genomics.The Journal of pathology · 2026Review
- T-lymphoblastic leukemia/lymphoma: a comprehensive review of pathology, molecular features, and differential diagnosis.Journal of pathology and translational medicine · 2026Article
- Plasticity under pressure: biology and detection of lineage switch in acute leukemia.Leukemia · 2026Review
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- The partner gene modulates response to asciminib in ABL1-rearranged Acute Lymphoblastic Leukemia.Neoplasia (New York, N.Y.) · 2026Article
- The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groups.HemaSphere · 2026Article
- Tumor-induced dendritic cell deregulation perturbs T cell proliferation and predicts clinical outcome in acute lymphoblastic leukemia.Cell reports. Medicine · 2026Article
- Measurable residual disease detected by next-generation sequencing in T-cell acute lymphoblastic leukemia.Nature communications · 2026Article
- Dynamic expression of CD9 protein in T-cell acute lymphoblastic leukemia.Cancer gene therapy · 2026Article
- Article
- Targeting Menin in T-lineage Acute Lymphoblastic Leukemia.Molecular cancer therapeutics · 2026Article
- Not Missing the Notch: Detection Challenges of Juxtamembrane NOTCH1 Variant Detection in T-Cell Acute Lymphoblastic Leukemia.Journal of clinical laboratory analysis · 2026Article
- Co-option of lineage plasticity as a hallmark of multipotent acute leukemias.Blood neoplasia · 2026Review
- clinTALL: machine learning-driven multimodal subtype classification and treatment outcome prediction in pediatric T-ALL.Genome medicine · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors.
Petri PölönenDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-6128-9985
Danika Di Giacomo *Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-5558-7967
Anna Eames Seffernick *Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0848-4604
Abdelrahman ElsayedDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
Shunsuke KimuraDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2158-467X
Francesca BeniniDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2900-6636
Lindsey E MontefioriDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2342-6349
Brent L WoodChildren's Hospital Los Angeles, Laboratory Medicine, Los Angeles, CA, USA.
Jason XuPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Changya ChenDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zhongshan ChengCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.
Haley NewmanDepartment of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jason MyersCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0341-0860
Ilaria IacobucciDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2008-1365
Elizabeth LiDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jonathan SussmanPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3057-3550
Dale HedgesCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.
Yawei HuiCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.
Caroline DiorioPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lahari UppuluriDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-7217-892X
David FrankPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yiping FanCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.
Yunchao ChangDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0009-0005-3906-5543
Soheil MeshinchiFred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA.
Rhonda RiesFred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA.ORCID 0000-0002-3702-7923
Rawan ShraimDepartment of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alexander LiDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kathrin M BerntPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0691-356X
Meenakshi DevidasGlobal Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1099-3478
Stuart S WinterResearch Institute and Cancer and Blood Disorders Program, Children's Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-3583-7727
Kimberly P DunsmoreDivision of Oncology, University of Virginia Children's Hospital, Charlottesville, VA, USA.
Hiroto InabaDepartment of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0605-7342
William L CarrollDivision of Pediatric Hematology Oncology, Department of Pediatrics, NYU Langone Health, New York, NY, USA.
Nilsa C RamirezDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Aaron H PhillipsDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Richard W KriwackiDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-9798-6018
Jun J YangDepartment of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0770-9659
Tiffaney L VincentDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yaqi ZhaoDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-8230-5312
Pankaj S GhateDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-6678-781X
Jian WangDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Colleen ReillyDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3119-9940
Xin ZhouDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3979-8200
Mathijs A SandersDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Junko TakitaDepartment of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto, Japan.
Motohiro KatoDepartment of Pediatrics, Tokyo University, Tokyo, Japan.
Nao TakasugiDepartment of Pediatrics, Tokyo University, Tokyo, Japan.
Bill H ChangDepartment of Pediatrics, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0003-3783-1820
Richard D PressDepartment of Pathology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-2103-5144
Mignon LohDepartment of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4099-4700
Evadnie RampersaudCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.
Elizabeth RaetzDivision of Pediatric Hematology Oncology, Department of Pediatrics, NYU Langone Health, New York, NY, USA.
Stephen P HungerPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kai TanPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ti-Cheng ChangCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-5302-9147
Gang WuCenter for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1678-5864
Stanley B PoundsDepartment of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-9167-2114
Charles G MullighanDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.ORCID 0000-0002-1871-1850
David T TeacheyPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. teacheyd@chop.edu.ORCID 0000-0001-7373-8987
Funding
NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MCOG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8MCOG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5MPhysician Scientist Training in Clinical OncologyK12CA076931 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STEPHEN Patrick HUNGER, LYNN M. SCHUCHTER · 1997 to 2026
$16.5MSupport for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5MTranslating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4MProject 4U54CA243124 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MULLIGHAN, CHARLES G. · 2019 to 2023
$10.5MCANCER RESEARCH TRAINING PROGRAMT32CA009615 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Gregory L Beatty, MICHAEL D HOGARTY · 1988 to 2026
$10.4MImproving risk allocation and developing novel therapies for children with T-ALL and T-LLR01CA193776 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Terzah M Horton, ADAM B OLSHEN · 2015 to 2026
$6.2MBiomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemiaR01CA264837 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TEACHEY, DAVID T., YANG, JUN J. · 2021 to 2025
$3.0MChildhood Hematological Malignancies Training ProgramT32CA236748 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2019 to 2026
$2.0MNCI NIH HHS F32 CA254140NCI NIH HHS K12 CA076931NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA193776NCI NIH HHS R01 CA264837NCI NIH HHS R03 CA256550NCI NIH HHS R35 CA197695NCI NIH HHS T32 CA236748NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA114766NCI NIH HHS U24 CA196173NCI NIH HHS U54 CA243124NIGMS NIH HHS R01 GM115634
Abstract
T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour
Indexed as
Genome, HumanGenomicsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaChildChromatinEnhancer Elements, GeneticEpigenomicsFemaleGene Expression Regulation, LeukemicHumansMaleSingle-Cell AnalysisT-LymphocytesTranscriptomeChromatin
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT06855810ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.