Evidence map›Paper›PMID 39143223›Full record

ArticleNature2024

Continuously fluctuating selection reveals fine granularity of adaptation.

M C Bitter, S Berardi, H Oken, A Huynh, Egor Lappo, P Schmidt, D A Petrov

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026
    Article
  5. Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

M C BitterDepartment of Biology, Stanford University, Stanford, CA, USA. mcbitter@stanford.edu.ORCID 0000-0001-7607-2375
S BerardiDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0009-0627-8007
H OkenDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
A HuynhDepartment of Biology, Stanford University, Stanford, CA, USA.
Egor LappoDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0847-4070
P SchmidtDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA. schmidtp@sas.upenn.edu.ORCID 0000-0002-8076-6705
D A PetrovDepartment of Biology, Stanford University, Stanford, CA, USA. dpetrov@stanford.edu.ORCID 0000-0002-3664-9130

Funding

Genomics of rapid adaptation in the lab and in the wildR35GM118165 · NIGMS · STANFORD UNIVERSITY · PI Dmitri Petrov · 2016 to 2026
$8.3M
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotypeR01GM137430 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MCINTYRE, LAUREN M., SCHMIDT, PAUL · 2021 to 2024
$2.2M
NIGMS NIH HHS R01 GM137430NIGMS NIH HHS R35 GM118165
6 · The paper itself

Abstract

Temporally fluctuating environmental conditions are a ubiquitous feature of natural habitats. Yet, how finely natural populations adaptively track fluctuating selection pressures via shifts in standing genetic variation is unknown

Indexed as

Adaptation, PhysiologicalDrosophila melanogasterGenetic FitnessGenetic VariationSelection, GeneticAnimalsFemaleGene FrequencyGenetic DriftGenome, InsectMalePopulation DensityPopulation DynamicsSeasonsStochastic ProcessesTime Factors

Identifiers

PMID39143223
PMCPMC13227946

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.