Evidence map›Paper›PMID 39143209›Full record

ArticleNature2024

Human organoids with an autologous tissue-resident immune compartment.

Timothy Recaldin, Linda Steinacher, Bruno Gjeta, Marius F Harter, Lukas Adam, Kristina Kromer, Marisa Pimentel Mendes, Marina Bellavista, Mikhail Nikolaev, Giacomo Lazzaroni and 10 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed.

  1. A Tissue Explant Model for Colon Cancer.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Review
  3. Article
  4. Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  12. Review
  13. Review
  14. Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  15. Review
  16. Review
  17. Recent advancements and limitations of intestinal organoids for clinical applications.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  18. Review
  19. Review
  20. New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026
    Review

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Timothy Recaldin *Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland.
Linda Steinacher *Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland.ORCID 0000-0001-6326-7982
Bruno Gjeta *Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Marius F Harter *Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Lukas AdamInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Kristina KromerInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Marisa Pimentel MendesRoche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland.ORCID 0009-0006-6984-9581
Marina BellavistaInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.ORCID 0009-0000-1496-4183
Mikhail NikolaevInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.ORCID 0000-0001-5955-900X
Giacomo LazzaroniRoche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland.
Rok KreseInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Umut KilikInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Doris PopovicInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Bilgenaz StollInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.ORCID 0000-0001-9816-9530
Régine GerardInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.
Michael BscheiderRoche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland.
Marc BickleInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland.ORCID 0000-0002-8918-1869
Lauriane CabonInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland. lauriane.cabon@roche.com.ORCID 0000-0001-8472-2227
J Gray CampInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland. gray.camp@roche.com.ORCID 0000-0003-3295-1225
Nikolche GjorevskiInstitute of Human Biology (IHB), Roche Pharma Research and Early Development, Basel, Switzerland. nikolche.gjorevski@roche.com.ORCID 0000-0001-8320-0443

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intimate relationship between the epithelium and immune system is crucial for maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease and cancer

Indexed as

IntestinesOrganoidsAdultAgedAged, 80 and overCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MovementEpithelial CellsFemaleHumansImmunotherapyInflammationIntestinal MucosaMaleMemory T Cells

Identifiers

PMID39143209
PMCPMC11374719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.