ArticleNature2024
Remodelling of the translatome controls diet and its impact on tumorigenesis.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
- Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription.Nature chemical biology · 2026Article
- Hepatic translational rewiring in insulin deficiency identifies Reg3α as an insulin-independent glucoregulatory factor.Endocrinology · 2026Article
- Discovery of a small-molecule inhibitor of eIF4E suppressing tumor proliferation via lipid metabolic reprogramming.Journal of advanced research · 2026Article
- Review
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- Ribo-Tweezer: Rapid removal of ribosomal proteins reveals additional layers of post-transcriptional gene regulation.Molecular cell · 2026Article
- Preliminary In Vitro Screening of Structure-Dependent β-Hydroxybutyrate Responses to Dietary Fatty Acids in Hepatocyte Models.Nutrients · 2026Article
- Therapeutic targeting of the eIF4E cap-binding domain reveals control of lineage fate in prostate cancer.The Journal of clinical investigation · 2026Article
- Article
- A ketogenic diet sensitizes pancreatic cancer to glutamine metabolism inhibitors.Cell reports. Medicine · 2026Article
- The advent of precision nutrigeroscience in cancer: from clinic towards molecular biology.Journal of advanced research · 2026Review
- Nutritional modulation of metabolic signaling within the tumor microenvironment for cancer therapy.Molecular and cellular biochemistry · 2026Review
- ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury.Circulation · 2026Article
- Remodeling the tumor dormancy ecosystem to prevent recurrence and metastasis.Signal transduction and targeted therapy · 2026Review
- Novel LncRNA Gm44763 Regulates Morphine-Induced Reward Memory via MiR-298-5p-Mediated eIF4E Translation Control.Research (Washington, D.C.) · 2026Article
- AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis.Nature metabolism · 2026Review
- Strategic modulation of the gastrointestinal microbiome to enhance pancreatic cancer immunotherapy.Drug discovery today · 2025Review
- Alteration of cardiac energetics and mitochondrial function in doxorubicin‑induced cardiotoxicity: Molecular mechanism and prospective implications (Review).International journal of molecular medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Haojun YangHelen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.ORCID 0000-0003-2685-3899
Vincenzo Andrea ZingaroHelen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
James LincoffDepartment of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA.ORCID 0000-0003-3090-1240
Harrison TomHelen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.ORCID 0000-0001-9402-2371
Satoshi OikawaDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA.ORCID 0000-0002-7696-8128
Juan A Oses-PrietoDepartment of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA.ORCID 0000-0003-4759-2341
Quinn EdmondsonDepartment of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA.
Ian SeipleDepartment of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA.ORCID 0000-0002-8732-1362
Hardik ShahMetabolomics Platform, Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-8408-5686
Shingo KajimuraDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA.ORCID 0000-0003-0672-5910
Alma L BurlingameHelen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.ORCID 0000-0002-8403-7307
Michael GrabeDepartment of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA.ORCID 0000-0003-3509-5997
Davide RuggeroHelen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA. Davide.Ruggero@ucsf.edu.ORCID 0000-0002-9444-5865
Funding
Mechanisms of regulated translation control in cancer and its therapeutic implicationsR35CA242986 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUGGERO, DAVIDE · 2019 to 2025
$6.4MResearch Training in Chemistry and Chemical BiologyT32GM145460 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason E Gestwicki · 2022 to 2026
$3.1MMolecular control of beige fat heterogeneityR01DK125281 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2020 to 2023
$1.9MIon permeation, lipid flipping, and membrane remodeling by TMEM16 proteinsR01GM137109 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRABE, MICHAEL · 2021 to 2024
$1.4MNCI NIH HHS R35 CA242986NIDDK NIH HHS R01 DK125281NIGMS NIH HHS R01 GM137109NIGMS NIH HHS T32 GM145460
Abstract
Fasting is associated with a range of health benefits
Indexed as
CarcinogenesisFatty AcidsKetone BodiesProtein BiosynthesisSignal Transduction5' Untranslated RegionsAMP-Activated Protein KinasesAnimalsDiet, KetogenicEukaryotic Initiation Factor-4EFastingFemaleHepatocytesHumansLipid MetabolismMice5' Untranslated RegionsAMP-Activated Protein KinasesEukaryotic Initiation Factor-4EFatty AcidsKetone BodiesProtein Serine-Threonine KinasesPyridinesPyrimidinestomivosertib
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.