ArticlePediatric research2025
Methodological considerations on diffusion MRI tractography in infants aged 0-2 years: a scoping review.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Phylum level differences in the gut bacteria of nursing infants and growth-related decreases in iron reserves are associated with the microstructural organization of cortical white matter tracts in rhesus monkeys.Neurobiology of stress · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Cross-population white matter atlas creation for concurrent mapping of brain connections in neonates and adults with diffusion MRI tractography.Fundamental research · 2026Article
- A Novel Fixel-Based Approach for Resolving Neonatal White Matter Microstructure from Clinical Diffusion MRI.medRxiv : the preprint server for health sciences · 2026Article
- A novel fixel-based approach for resolving neonatal white matter microstructure from clinical diffusion MRI.Frontiers in neuroscience · 2026Article
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Authors and funding
7 authors.
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Abstract
Diffusion MRI (dMRI) enables studying the complex architectural organization of the brain's white matter (WM) through virtual reconstruction of WM fiber tracts (tractography). Despite the anticipated clinical importance of applying tractography to study structural connectivity and tract development during the critical period of rapid infant brain maturation, detailed descriptions on how to approach tractography in young infants are limited. Over the past two decades, tractography from infant dMRI has mainly been applied in research settings and focused on diffusion tensor imaging (DTI). Only few studies used techniques superior to DTI in terms of disentangling information on the brain's organizational complexity, including crossing fibers. While more advanced techniques may enhance our understanding of the intricate processes of normal and abnormal brain development and extensive knowledge has been gained from application on adult scans, their applicability in infants has remained underexplored. This may partially be due to the higher technical requirements versus the need to limit scan time in young infants. We review various previously described methodological practices for tractography in the infant brain (0-2 years-of-age) and provide recommendations to optimize advanced tractography approaches to enable more accurate reconstructions of the brain WM's complexity. IMPACT: Diffusion tensor imaging is the technique most frequently used for fiber tracking in the developing infant brain but is limited in capability to disentangle the complex white matter organization. Advanced tractography techniques allow for reconstruction of crossing fiber bundles to better reflect the brain's complex organization. Yet, they pose practical and technical challenges in the fast developing young infant's brain. Methods on how to approach advanced tractography in the young infant's brain have hardly been described. Based on a literature review, recommendations are provided to optimize tractography for the developing infant brain, aiming to advance early diagnosis and neuroprotective strategies.
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