ArticleNature communications2024
Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Subset-based method for cross-tissue transcriptome-wide association studies improves power and interpretability.HGG advances · 2024Pooled it
- Mendelianization: Concentrating Polygenic Signal Into a Single Causal Locus.Genetic epidemiology · 2026Article
- Research on multi-trait genome association study method based on Shannon information entropy.BMC bioinformatics · 2026Article
- Large-Scale Analyses of GWAS Identify Five Key Pleiotropic Genes Involved in Complex Diseases.Genes · 2026Article
- Cross-trait mapping of shared susceptibility across inflammatory bowel disease and spondyloarthropathies.Journal of translational medicine · 2026Article
- Using Importance Sampling to EstimateArXiv · 2026Article
- Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning.Cell genomics · 2026Article
- Partitioning genetic pleiotropy within tissue-specific regulatory patterns.Cell genomics · 2026Article
- Dissecting pleiotropy to gain mechanistic insights into human disease.Nature reviews. Genetics · 2026Review
- Article
- PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores.bioRxiv : the preprint server for biology · 2025Article
- A one-shot, lossless algorithm for cross-cohort learning in mixed-outcomes analysis.Patterns (New York, N.Y.) · 2025Article
- Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components.American journal of human genetics · 2025Article
- Shared loci but distinct variants underlie genetic architecture of allergic diseases.medRxiv : the preprint server for health sciences · 2025Article
- Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning.medRxiv : the preprint server for health sciences · 2025Article
- Specificity, length, and luck: How genes are prioritized by rare and common variant association studies.bioRxiv : the preprint server for biology · 2024Article
- Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants.Nature communications · 2024Article
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7 authors.
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Abstract
Genome-wide association studies (GWAS) have found widespread evidence of pleiotropy, but characterization of global patterns of pleiotropy remain highly incomplete due to insufficient power of current approaches. We develop fastASSET, a method that allows efficient detection of variant-level pleiotropic association across many traits. We analyze GWAS summary statistics of 116 complex traits of diverse types collected from the GRASP repository and large GWAS Consortia. We identify 2293 independent loci and find that the lead variants in nearly all these loci (~99%) to be associated with
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