Evidence map›Paper›PMID 39142966›Full record

ArticleChinese journal of traumatology = Zhonghua chuang shang za zhi2025

Empirical and modified hemostatic resuscitation for liver blast injury combined with seawater immersion: A preliminary study.

Haoyang Yang, Chenglin Dai, Dongzhaoyang Zhang, Can Chen, Zhao Ye, Xin Zhong, Yijun Jia, Renqing Jiang, Wenqiong Du, Zhaowen Zong

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Article in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Haoyang YangState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Chenglin DaiState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Dongzhaoyang ZhangState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Can ChenState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Zhao YeState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Xin ZhongState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Yijun JiaState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Renqing JiangState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Wenqiong DuState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China.
Zhaowen ZongState Key Laboratory of Trauma, Burn and Combined Injury, Department for Combat Casualty Care Training, Army Medical University, Chongqing, 400037, China. Electronic address: zongzhaowen@tmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the effects of empirical and modified hemostatic resuscitation for liver blast injury combined with seawater immersion.

methodsThirty rabbits were subjected to liver blast injury combined with seawater immersion, and were then divided into 3 groups randomly (n = 10 each): group A (no treatment after immersion), group B (empirical resuscitation with 20 mL hydroxyethyl starch, 50 mg tranexamic acid, 25 IU prothrombin complex concentrate and 50 mg/kg body weight fibrinogen concentrate), and group C (modified resuscitation with additional 10 IU prothrombin complex concentrate and 20 mg/kg body weight fibrinogen concentrate based on group B). Blood samples were gathered at specified moments for assessment of thromboelastography, routine coagulation test, and biochemistry. Mean arterial pressure, heart rate, and survival rate were also documented at each time point. The Kolmogorov-Smirnov test was used to examine the normality of data distribution. Multigroup comparisons were conducted with one-way ANOVA.

resultsLiver blast injury combined with seawater immersion resulted in severe coagulo-fibrinolytic derangement as indicated by prolonged prothrombin time (s) (11.53 ± 0.98 vs. 7.61 ± 0.28, p＜0.001), activated partial thromboplastin time (APTT) (s) (33.48 ± 6.66 vs. 18.23 ± 0.89, p＜0.001), reaction time (R) (min) (5.85 ± 0.96 vs. 2.47 ± 0.53, p＜0.001), decreased maximum amplitude (MA) (mm) (53.20 ± 5.99 vs. 74.92 ± 5.76, p＜0.001) and fibrinogen concentration (g/L) (1.19 ± 0.29 vs. 1.89 ± 0.32, p = 0.003), and increased D-dimer concentration (mg/L) (0.38 ± 0.32 vs. 0.05 ± 0.03, p = 0.005). Both empirical and modified hemostatic resuscitation could improve the coagulo-fibrinolytic states and organ function, as indicated by shortened APTT and R values, decreased D-dimer concentration, increased fibrinogen concentration and MA values, lower concentration of blood urea nitrogen and creatine kinase-MB in group B and group C rabbits in comparison to that observed in group A. Further analysis found that the R values (min) (4.67 ± 0.84 vs. 3.66 ± 0.98, p = 0.038), APTT (s) (23.16 ± 2.75 vs. 18.94 ± 1.05, p = 0.001), MA (mm) (60.10 ± 4.74 vs. 70.21 ± 3.01, p < 0.001), and fibrinogen concentration (g/L) (1.68 ± 0.21 vs. 1.94 ± 0.16, p = 0.013) were remarkably improved in group C than in group B at 2 h and 4 h after injury. In addition, the concentration of blood urea nitrogen (mmol/L) (24.11 ± 1.96 vs. 21.00 ± 3.78, p = 0.047) and creatine kinase-MB (U/L) (85.50 ± 13.60 vs. 69.74 ± 8.56, p = 0.013) were lower in group C than in group B at 6 h after injury. The survival rates in group B and group C were significantly higher than those in group A at 4 h and 6 h after injury (p < 0.001), however, there were no statistical differences in survival rates between group B and group C at each time point.

conclusionsModified hemostatic resuscitation could improve the coagulation parameters and organ function better than empirical hemostatic resuscitation.

Indexed as

Blast InjuriesLiverResuscitationSeawaterAnimalsFibrinogenHydroxyethyl Starch DerivativesImmersionMaleRabbitsTranexamic AcidFibrinogenHydroxyethyl Starch DerivativesTranexamic AcidCoagulation-fibrinolytic derangementHemostatic resuscitationLiver blast injurySeawater immersionTraumatic coagulopathy

Identifiers

PMID39142966
PMCPMC12166878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.