Evidence map›Paper›PMID 39142810›Full record

ArticleGenome research2024

A spatiotemporally resolved atlas of mRNA decay in the

Felicia Peng, C Erik Nordgren, John Isaac Murray

Abstract read
In one paragraph

Article in Genome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Novel Silent Mutations in theAnimals : an open access journal from MDPI · 2025
    Article
  4. Article
  5. Article
  6. Landscape and regulation of mRNA translation in the earlybioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Felicia PengDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0001-8733-0907
C Erik NordgrenDepartment of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0002-5024-0278
John Isaac MurrayDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; jmurr@pennmedicine.upenn.edu.ORCID 0000-0003-4026-584X

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
Decoding lineage and fate specification in the C. elegans embryoR35GM127093 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MURRAY, JOHN ISAAC · 2018 to 2022
$2.0M
Decoding lineage and fate specification in the C. elegans embryoR35GM153497 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI John Isaac Murray · 2024 to 2026
$1.3M
NIGMS NIH HHS R35 GM127093NIGMS NIH HHS R35 GM153497NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

During embryonic development, cells undergo dynamic changes in gene expression that are required for appropriate cell fate specification. Although both transcription and mRNA degradation contribute to gene expression dynamics, patterns of mRNA decay are less well understood. Here, we directly measure spatiotemporally resolved mRNA decay rates transcriptome-wide throughout

Indexed as

Caenorhabditis elegansGene Expression Regulation, DevelopmentalRNA, MessengerRNA StabilityAnimalsCaenorhabditis elegans ProteinsEmbryonic DevelopmentEmbryo, NonmammalianTranscriptomeCaenorhabditis elegans ProteinsRNA, Messenger

Identifiers

PMID39142810
PMCPMC11444186

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.