SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2024
A systematic review of procedural and sampling techniques for cryobiopsy in interstitial lung disease.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Yield and safety of different biopsy types in interstitial lung disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Transbronchial Lung Cryobiopsy and Awake Video-Assisted Thoracic Surgery in Interstitial Lung Disease: Complementary Roles in a Stepwise Diagnostic Approach.Diagnostics (Basel, Switzerland) · 2026Review
- Advancing Transbronchial Lung Cryobiopsy in Interstitial Lung Disease with Adjunctive Tools and Smaller Cryoprobes.Journal of clinical medicine · 2026Review
- Diagnostic Yield and Safety of Radial Probe Endobronchial Ultrasound-Guided Transbronchial Lung Cryobiopsy with a Guide Sheath in Pulmonary Lesions < 3 cm.Diagnostics (Basel, Switzerland) · 2026Article
- Intraductal cryobiopsy via percutaneous cholangioscopy for biliary strictures: a multicenter feasibility study.Endoscopy · 2026Article
- Transbronchial lung cryobiopsy and surgical lung biopsy for interstitial lung diseases: a cost-effectiveness analysis.Respiratory research & clinical practice · 2026Article
- Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows.Frontiers in medicine · 2026Review
- Pulmonary lymphangitic carcinomatosis and pathological fracture as the initial manifestations of occult gastric adenocarcinoma mimicking interstitial lung disease: a case report and review of the literature.Frontiers in medicine · 2026Article
- Diagnostic yield and safety of transbronchial lung cryobiopsy using 1.7-mm probes in interstitial lung disease.Journal of thoracic disease · 2025Article
- The Role of Bronchoscopy in the Diagnosis of Interstitial Lung Disease: A State-of-the-Art Review.Journal of clinical medicine · 2025Review
- Impact of biopsy number and radiologic pattern on diagnostic yield and complications of transbronchial lung cryobiopsy in interstitial lung diseases: a multi-center retrospective study.Journal of thoracic disease · 2025Article
- The Impact of Adverse Events in Transbronchial Lung Cryobiopsy on Histopathological Diagnosis.Journal of clinical medicine · 2025Article
- Resources in the bronchoscopy suite and the utility of cryobiopsy.African journal of thoracic and critical care medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransbronchial lung cryobiopsy (TBLC) is an alternative to surgical lung biopsy for histopathological evaluation of unclassifiable interstitial lung disease (ILD) or ILD diagnosed with low confidence. This meta-analysis synthesised current literature regarding cryobiopsy diagnostic performance and safety, focusing on procedural and sampling techniques.
methodsMedline and Embase were searched on 11 April 2022. Studies included adults with unclassifiable ILD, reporting diagnostic yield, complications and methodological techniques of TBLC. Meta-analyses were performed for diagnostic yield, pneumothorax and bleeding. Subgroup analyses and meta-regression assessed methodological variables. PROSPERO registration: CRD42022312386.
results70 studies were included with 6183 participants. Diagnostic yield of TBLC was 81% (95% CI 79-83%, I
interpretationPatient characteristics and modifiable factors, including procedural methods and anaesthetic techniques, impacted diagnostic yield and safety outcomes of TBLC in people with unclassifiable ILD and contributed to heterogeneity of clinical outcomes. These variables should be considered for individualised clinical decision making and guideline development and warrant routine reporting in future research.
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