Evidence map›Paper›PMID 39142692›Full record

ArticleRMD open2024

More severe parotid gland histopathology in paediatric-onset than in adult-onset Sjögren's disease.

Geertje Elizabeth Legger, Uzma Nakshbandi, Martha S van Ginkel, Silvia C Liefers, Lisette de Wolff, Alja J Stel, Wineke Armbrust, Fred K L Spijkervet, Arjan Vissink, Suzanne Arends and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Geertje Elizabeth LeggerPediatric Rheumatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands g.e.legger@umcg.nl.ORCID 0000-0002-9576-0904
Uzma NakshbandiRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-5253-1888
Martha S van GinkelRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-0867-0282
Silvia C LiefersOral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Lisette de WolffRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-7917-5449
Alja J StelRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Wineke ArmbrustPediatric Rheumatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Fred K L SpijkervetOral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Arjan VissinkOral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Suzanne ArendsRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-4422-7640
Hendrika BootsmaRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bert van der VegtPathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Gwenny M VerstappenRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Frans G M KroeseRheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to assess the histopathological features of the parotid glands in patients with paediatric-onset Sjögren's disease (pedSjD) in comparison to patients with adult-onset Sjögren's disease (adSjD).

methodsThis study was performed in Groningen, the Netherlands. Patients with pedSjD from a diagnostic paediatric cohort (n=19), patients with adSjD from a diagnostic adult cohort (n=32) and patients with adSjD who participated in a clinical trial (n=42) with a baseline parotid gland biopsy were included. Parotid gland biopsies were analysed after (immuno)histological staining for SjD-related histopathological markers and compared between groups.

resultsAll characteristic histopathological features of adSjD were also observed in pedSjD. There were no significant differences in lymphoepithelial lesions or immunoglobulin A (IgA)/IgG plasma cell shift between the pedSjD and the adSjD cohorts. However, compared with the diagnostic adSjD cohort (with comparable total EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) scores), pedSjD showed more severe lymphocytic infiltration as reflected by a higher focus score (p=0.003), a higher relative surface area of CD45+ infiltrate (p=0.041), higher numbers of B and T lymphocytes/mm

conclusionPatients with pedSjD exhibit more pronounced histopathological features compared with patients with adSjD at diagnosis. Notably, the histopathology of patients with pedSjD aligns more closely with that observed in an adSjD clinical trial cohort, with even stronger B lymphocyte involvement.

Indexed as

Age of OnsetParotid GlandSjogren's SyndromeAdolescentAdultAgedBiomarkersBiopsyChildFemaleHumansMaleMiddle AgedNetherlandsSeverity of Illness IndexYoung AdultBiomarkersAutoimmune DiseasesB-LymphocytesChildInflammationSjogren's Syndrome

Identifiers

PMID39142692
PMCPMC11332018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.