Evidence map›Paper›PMID 39142287›Full record

ArticleCurrent biology : CB2024

Light and dopamine impact two circadian neurons to promote morning wakefulness.

Jasmine Quynh Le, Dingbang Ma, Xihuimin Dai, Michael Rosbash

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Cell-type-specific circadian and light-responsive transcriptional dynamics in adultProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  6. The use ofFrontiers in cell and developmental biology · 2026
    Review
  7. A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jasmine Quynh LeHoward Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02453, USA.
Dingbang MaHoward Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02453, USA; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Xihuimin DaiHoward Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02453, USA.
Michael RosbashHoward Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02453, USA. Electronic address: rosbash@brandeis.edu.

Funding

NEUROSCIENCE: FROM CHANNELS TO BEHAVIORT32MH019929 · NIMH · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 1994 to 2023
$8.5M
GENETIC AND BIOCHEMICAL MECHANISMS OF REGULATIONT32GM007122 · NIGMS · BRANDEIS UNIVERSITY · PI LOVETT, SUSAN THOMAS · 1985 to 2020
$7.5M
Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM007122NIMH NIH HHS RF1 MH117815NIMH NIH HHS T32 MH019929NINDS NIH HHS U24 NS126935
6 · The paper itself

Abstract

In both mammals and flies, circadian brain neurons orchestrate physiological oscillations and behaviors like wake and sleep-these neurons can be subdivided by morphology and by gene expression patterns. Recent single-cell sequencing studies identified 17 Drosophila circadian neuron groups. One of these includes only two lateral neurons (LNs), which are marked by the expression of the neuropeptide ion transport peptide (ITP). Although these two ITP

Indexed as

Circadian RhythmDopamineDrosophila melanogasterDrosophila ProteinsNeuronsReceptors, DopamineWakefulnessAnimalsLightDop1R1 protein, DrosophilaDopamineDrosophila ProteinsReceptors, DopamineactivitycAMPcircadian neuronsCRISPR-Cas9cyclingDop1R1dopamineDrosophilaGPCRsleep

Identifiers

PMID39142287
PMCPMC11404089

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.