Evidence map›Paper›PMID 39141922›Full record

ArticleTopics in antiviral medicine2024

The Challenge of Adherence to a Complex Antiretroviral Therapy Regimen in an Individual With Multidrug-Resistant HIV.

Marco Moretti, Karolien Stoffels, Kristel Van Laethem, Chris Verhofstede, Sigi Van Den Wijngaert, Charlotte Martin

Abstract readCase Reports
In one paragraph

Article in Topics in antiviral medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Combined Use of Ibalizumab and Lenacapavir for the Treatment of Multidrug-resistant HIV-1: A Case Series.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marco MorettiVrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel (UZB), Belgium; Université Libre de Bruxelles (ULB).
Karolien StoffelsCentre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium.
Kristel Van LaethemRega Institute for Medical Research, KU Leuven, Belgium; University Hospitals Leuven, Belgium.
Chris VerhofstedeGhent University, Belgium.
Sigi Van Den WijngaertCentre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium.
Charlotte MartinUniversité Libre de Bruxelles (ULB), Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited therapeutic options are available for patients with multidrug-resistant HIV. This report describes a 38-year-old female who was perinatally infected with HIV-1 and treated with 14 different antiretroviral regimens over 27 years, gradually leading to 4-class drug resistance. Despite various attempts to obtain sustained viral suppression, including the off-label administration of intravenous foscarnet and enfuvirtide, and thorough follow-up with 16 viral genotyping/phenotyping from 1999 to 2021, viral control was not maintained. Recently, the introduction of a regimen with fostemsavir and lenacapavir resulted in long-term viral suppression.

Indexed as

Anti-HIV AgentsDrug Resistance, Multiple, ViralHIV-1HIV InfectionsAdultAntiretroviral Therapy, Highly ActiveFemaleHumansMedication AdherenceViral LoadAnti-HIV Agents

Identifiers

PMID39141922
PMCPMC11293606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.