ArticleThe New England journal of medicine2024
Longevity of a Brain-Computer Interface for Amyotrophic Lateral Sclerosis.
2 registry-linked trialsAbstract readCase Reports
In one paragraph
Article in The New England journal of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utrecht Neural Prosthesis (UNP): A Pilot Study on Controllability of Brain Signals and Application in locked-in Patients
Investigation on the Cortical Communication (CortiCom) System
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Toward the Clinical Translation of Implantable Brain-Computer Interfaces for Motor Impairment: Research Trends and Outcome Measures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Pooled it
- Simultaneous speech and gesture decoding for multimodal communication in paralysis.Nature neuroscience · 2026Article
- Ethical considerations for implantable human brain-computer interfaces.Nature neuroscience · 2026Article
- Article
- Optimal Size of Electrocorticography Grids for Classification of Hand Movements.Neuroinformatics · 2026Article
- Multimodal Assessment of Consciousness with Brain-Computer Interfaces and Artificial Intelligence: From Acquired Brain Injury to Neurodegenerative Disease.Journal of clinical medicine · 2026Review
- Association between motor cortex grey matter loss and inability to control an ECoG-based implanted Brain-Computer Interface in ALS.medRxiv : the preprint server for health sciences · 2026Article
- Long-term independent use of an intracortical brain-computer interface for speech and cursor control.Nature medicine · 2026Article
- Intracortical brain-computer interface for navigation in virtual reality in macaque monkeys.Science advances · 2026Article
- Ethical Guidance for Investigational Implantable Neural Device Studies: Recommendations for Researchers and Research Ethics Committees.Neuromodulation : journal of the International Neuromodulation Society · 2026Review
- Optimal location for gesture decoding in the sensorimotor cortex and implications for brain-computer interface research.NeuroImage · 2026Article
- Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations.Nature communications · 2026Article
- Decoding intended speech with an intracortical brain-computer interface in a person with long-standing anarthria and locked-in syndrome.Cell reports · 2026Article
- Stable speech BCI performance during slow progression of ALS: A longitudinal ECoG study.Research square · 2026Article
- Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis.Scientific reports · 2026Article
- Article
- Optimal sensor set for MEG-based spontaneous and intended speech decoding toward practical communication.Frontiers in human neuroscience · 2026Article
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- Brain-Computer Interfaces for Vision Recovery in Precortical Vision Loss.Eye and brain · 2026Review
- Relational personhood: the missing link for evaluating clinical impact of brain-computer interfaces.Brain communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Mariska J VansteenselFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).ORCID 0000-0002-9252-5116
Sacha LeindersFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Mariana P BrancoFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Nathan E CroneFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Timothy DenisonFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Zachary V FreudenburgFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Simon H GeukesFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Peter H GosselaarFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Mathijs RaemaekersFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Anouck SchippersFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Malinda VerberneFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Erik J AarnoutseFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Nick F RamseyFrom the Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands (M.J.V., S.L., M.P.B., Z.V.F., S.H.G., P.H.G., M.R., A.S., M.V., E.J.A., N.F.R.); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (N.E.C.); and the Institute of Biomedical Engineering and the Department of Engineering Science, University of Oxford, Oxford, United Kingdom (T.D.).
Funding
Investigation of the Cortical Communication (CORTICOM) SystemUH3NS114439 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CRONE, NATHAN E, RAMSEY, NICOLAS FRANCISCUS · 2020 to 2025
$6.6MBrain-Computer Interface Implant for Severe Communication DisabilityU01DC016686 · NIDCD · UNIVERSITY MEDICAL CENTER UTRECHT · PI CRONE, NATHAN E, RAMSEY, NICOLAS FRANCISCUS · 2018 to 2021
$2.5MNederlandse Organisatie voor Wetenschappelijk Onderzoek INTENSE, 17619Netherlands Institute of Government UGT7685, Economic Affairs SSM06011 and STW 12803NIDCD NIH HHS U01 DC016686NIDCD NIH HHS U01DC016686NINDS NIH HHS UH3 NS114439NINDS NIH HHS UH3NS114439
Abstract
The durability of communication with the use of brain-computer interfaces in persons with progressive neurodegenerative disease has not been extensively examined. We report on 7 years of independent at-home use of an implanted brain-computer interface for communication by a person with advanced amyotrophic lateral sclerosis (ALS), the inception of which was reported in 2016. The frequency of at-home use increased over time to compensate for gradual loss of control of an eye-gaze-tracking device, followed by a progressive decrease in use starting 6 years after implantation. At-home use ended when control of the brain-computer interface became unreliable. No signs of technical malfunction were found. Instead, the amplitude of neural signals declined, and computed tomographic imaging revealed progressive atrophy, which suggested that ALS-related neurodegeneration ultimately rendered the brain-computer interface ineffective after years of successful use, although alternative explanations are plausible. (Funded by the National Institute on Deafness and Other Communication Disorders and others; ClinicalTrials.gov number, NCT02224469.).
Indexed as
Amyotrophic Lateral SclerosisAtrophyBrain-Computer InterfacesBrainCommunication Devices for People with DisabilitiesElectrodes, ImplantedFemaleHumansMiddle AgedTime FactorsTreatment Failure
Identifiers
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LicenceCC BY-ND
Read underepoch 390
Registered trials
NCT02224469ClinicalTrials.gov
NCT06207591ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.