Trial reportAesthetic surgery journal2024
Hyaluronic Acid Filler VYC-25L for Jawline Restoration Yields High Satisfaction, Improved Jawline Measurements, and Sustained Effectiveness Across Skin Types, Age, and Gender for up to 12 Months.
Trial report in Aesthetic surgery journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Durability of Hyaluronic Acid-Based Dermal Fillers for Facial Application: A Systematic Review.Aesthetic plastic surgery · 2026Pooled it
- VYC-25L Is Safe and Effective for Enhancing the Chin and Jawline by Correcting Chin Retrusion in Chinese Adults.Aesthetic surgery journal · 2025Trial
- Safe and Effective Restoration of Jawline Definition With Hyaluronic Acid Injectable Gel VYC-25L: Results From a Randomized Controlled Study.Aesthetic surgery journal · 2024Trial
- Assessment of Orofacial Function After Mandibular Angle Harmonization with Hyaluronic Acid: A Longitudinal Observational Study.Dentistry journal · 2026Article
- Structural Aesthetic Treatment With the Hyaluronic Acid Filler VYC-25L: Global Expert Considerations for Safe and Effective Long-Term Outcomes.Journal of cosmetic dermatology · 2025Article
- Piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) microspheres for collagen regeneration and skin rejuvenation.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundA randomized study previously reported demonstration of the safety and efficacy of hyaluronic acid filler VYC-25L for restoring jawline definition.
objectivesThe aim of this study was to evaluate patient-reported outcomes (PROs), objective changes in jawline profile, and safety and effectiveness measures by Fitzpatrick skin phototype (FST), gender, and age following VYC-25L treatment.
methodsAdults were randomized to receive VYC-25L (n = 157) or no treatment (control; n = 49) for 6 months. PROs were assessed by FACE-Q Satisfaction with Lower Face and Jawline, FACE-Q Appraisal of Lines: Marionette, and participant satisfaction with treatment questionnaires. Changes in jawline profile linear depth and volume were calculated with 3-dimensional digital image analysis. Responder rates, PROs, and injection site responses (ISRs) were assessed by FST, gender, and age.
resultsAt Month 6, >70% of treated participants responded "somewhat/very satisfied" to FACE-Q Satisfaction with Lower Face and Jawline questions, and ≥78% of treated participants responded "satisfied/definitely satisfied" with treatment overall. For participants treated for the marionette lines, the FACE-Q Appraisal of Lines: Marionette questionnaire mean score improved by 32.6 (baseline to Month 6). Mean change in linear depth in the prejowl sulcus in the treatment vs control groups was 4.6 mm vs 2.5 mm, respectively, and for jawline volume was 6.0 mL and -2.6 mL, respectively (baseline to Month 6). Subanalyses showed similar outcomes by FST, gender, and age, except for a numerically higher ISR incidence in females vs males.
conclusionsTreatment with VYC-25L to improve jawline definition yielded high patient satisfaction, objective improvements in jawline profile, and comparable effectiveness across various demographics. LEVEL OF EVIDENCE: 2:
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