Evidence map›Paper›PMID 39141569›Full record

ReviewAmerican journal of respiratory and critical care medicine2024

Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the Second International Post-Tuberculosis Symposium.

Sara C Auld, Amy K Barczak, William Bishai, Anna K Coussens, Intan M W Dewi, Steven C Mitini-Nkhoma, Caleb Muefong, Threnesan Naidoo, Anil Pooran, Cari Stek and 3 more

Abstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sara C AuldDepartments of Medicine, Epidemiology, and Global Health, Emory University School of Medicine and Rollins School of Public Health, Atlanta, Georgia.ORCID 0000-0002-8972-3736
Amy K BarczakDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0003-3806-2381
William BishaiDivision of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-8734-4118
Anna K CoussensInfectious Diseases and Immune Defence Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.ORCID 0000-0002-7086-2621
Intan M W DewiMicrobiology Division, Department of Biomedical Sciences, Faculty of Medicine, and.ORCID 0000-0002-4910-9651
Steven C Mitini-NkhomaMalawi Liverpool Wellcome Clinical Research Programme, Blantyre, Malawi.ORCID 0000-0002-3276-6890
Caleb MuefongDepartment of Microbiology, University of Chicago, Chicago, Illinois.ORCID 0000-0001-8817-9188
Threnesan NaidooDepartment of Forensic & Legal Medicine and.ORCID 0000-0002-1864-4301
Anil PooranCentre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, and.ORCID 0000-0001-5808-433X
Cari StekWellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-8813-0819
Adrie J C SteynAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.ORCID 0000-0001-9177-8827
Liku TezeraNational Institute for Health and Care Research Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-7898-6709
Naomi F WalkerDepartment of Clinical Sciences and Centre for Tuberculosis Research, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; and.ORCID 0000-0002-3345-7694

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Neel Rajnikant Gandhi, Jyothi Rengarajan · 2022 to 2026
$5.8M
Inflammation and Fibrosis in Pulmonary TB: the INFIN-TB StudyR01AI166988 · NIAID · EMORY UNIVERSITY · PI Sara Auld, GREGORY P. BISSON · 2022 to 2026
$5.1M
Genetic and hormonal mechanisms mediating sex differences in TB and TB-HIVR37AI167750 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WILLIAM Ramses BISHAI, SABRA L. KLEIN · 2022 to 2026
$3.3M
METABOLIC REPROGRAMMING OF T CELL ENERGY METABOLISM IN TUBERCULOSIS AND HIVR33AI138280 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2020 to 2023
$2.0M
Targeting MT1-MMP to inhibit pathologic inflammation in TBR21AI146813 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BARCZAK, AMY K · 2019 to 2020
$418k
Australia National Health and Medical Research Council GNT2020750German Federal Ministry of Education and Research 01KA2223BNational Institute of Allergy and Infectious Diseases R01AI166988National Institute of Allergy and Infectious Diseases R21AI146813National Institute of Allergy and Infectious Diseases R33AI138280National Institute of Allergy and Infectious Diseases R37AI167750NIAID NIH HHS P30 AI168386NIAID NIH HHS R01 AI166988NIAID NIH HHS R21 AI146813NIAID NIH HHS R33 AI138280NIAID NIH HHS R37 AI167750Research Networks for Health Innovations in Sub-Saharan Africa (RHISSA) TB-SEQUEL Network
6 · The paper itself

Abstract

Post-tuberculosis (post-TB) lung disease is increasingly recognized as a major contributor to the global burden of chronic lung disease, with recent estimates indicating that over half of TB survivors have impaired lung function after successful completion of TB treatment. However, the pathologic mechanisms that contribute to post-TB lung disease are not well understood, thus limiting the development of therapeutic interventions to improve long-term outcomes after TB. This report summarizes the work of the Pathogenesis and Risk Factors Committee for the Second International Post-Tuberculosis Symposium, which took place in Stellenbosch, South Africa, in April 2023. The committee first identified six areas with high translational potential:

Indexed as

Lung DiseasesTuberculosis, PulmonaryAnimalsCongresses as TopicHumansRisk FactorsSouth Africafibrosismatrix metalloproteinasesneutrophilspost-tuberculosis lung diseasetuberculosis

Identifiers

PMID39141569
PMCPMC11531093

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.