Evidence map›Paper›PMID 39141375›Full record

ArticleJournal of medicinal chemistry2024

Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for

Molly S Youse, Nader S Abutaleb, Alessio Nocentini, Abdallah S Abdelsattar, Farman Ali, Claudiu T Supuran, Mohamed N Seleem, Daniel P Flaherty

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Repurposing epetraborole to combatAntimicrobial agents and chemotherapy · 2026
    Article
  7. Drug Design of Carbonic Anhydrase Inhibitors.Sub-cellular biochemistry · 2026
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Molly S YouseBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Nader S AbutalebDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
Alessio NocentiniDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze 50122, Italy.ORCID 0000-0003-3342-702X
Abdallah S AbdelsattarDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
Farman AliBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Claudiu T SupuranDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze 50122, Italy.ORCID 0000-0003-4262-0323
Mohamed N SeleemDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.ORCID 0000-0003-0939-0458
Daniel P FlahertyBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-8305-0606

Funding

Repurposing novel selective drugs for treatment and decolonization of vancomycin resistant enterococciR01AI148523 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Daniel Patrick Flaherty, Mohamed Seleem · 2019 to 2026
$4.2M
Development of novel anti-Neisseria gonorrhoeae therapeutic agentsR01AI153264 · NIAID · PURDUE UNIVERSITY · PI FLAHERTY, DANIEL PATRICK · 2022 to 2025
$3.1M
Drug Discovery in Infectious Disease TrainingT32AI148103 · NIAID · PURDUE UNIVERSITY · PI STAHELIN, ROBERT VIRGIL, YEO, YOON · 2020 to 2024
$949k
NIAID NIH HHS R01 AI148523NIAID NIH HHS R01 AI153264NIAID NIH HHS T32 AI148103
6 · The paper itself

Abstract

Drug-resistant gonorrhea is caused by the bacterial pathogen

Indexed as

Anti-Bacterial AgentsEthoxzolamideNeisseria gonorrhoeaeAnimalsCaco-2 CellsCarbonic Anhydrase InhibitorsFemaleGonorrheaHumansMiceMicrobial Sensitivity TestsMicrosomes, LiverStructure-Activity RelationshipAnti-Bacterial AgentsCarbonic Anhydrase InhibitorsEthoxzolamide

Identifiers

PMID39141375
PMCPMC12168095

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.