Evidence map›Paper›PMID 39141356›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity.

Yinong Liu, Dan Hou, Wenzhe Chen, Xuan Lu, Garrison P Komaniecki, Yilai Xu, Tao Yu, Sophia M Zhang, Maurine E Linder, Hening Lin

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. ProteinJournal of pharmaceutical analysis · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yinong LiuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0009-0009-0405-5686
Dan HouDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0009-0003-9501-4180
Wenzhe ChenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-0758-1237
Xuan LuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Garrison P KomanieckiDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-1157-2667
Yilai XuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Tao YuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-7896-4625
Sophia M ZhangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Maurine E LinderDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2202-9712
Hening LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-0255-2701

Funding

Design and development of HDAC11-specific chemical inhibitors for disease treatmentsR01AI153110 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI LIN, HENING, MILLER, ROBERT H. · 2021 to 2025
$3.5M
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
HHMI (HHMI) NAHHS | NIH (NIH) R01AI153110NCRR NIH HHS S10 RR025502NIAID NIH HHS R01 AI153110
6 · The paper itself

Abstract

Cysteine palmitoylation or

Indexed as

AcyltransferasesAdaptor Proteins, Signal TransducingImmunity, InnateLipoylationMitochondrial MembranesAnimalsCysteineHEK293 CellsHumansMitochondriaProtein AggregatesSignal TransductionAcyltransferasesAdaptor Proteins, Signal TransducingCysteineMAVS protein, humanProtein Aggregatesantiviral innate immunityMAVSpalmitoylationtail-anchored proteinsZDHHC7

Identifiers

PMID39141356
PMCPMC11348129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.