Evidence map›Paper›PMID 39141351›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

An additional proofreader contributes to DNA replication fidelity in mycobacteria.

Ming-Zhi Deng, Qingyun Liu, Shu-Jun Cui, Yi-Xin Wang, Guoliang Zhu, Han Fu, Mingyu Gan, Yuan-Yuan Xu, Xia Cai, Sheng Wang and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Hypermutability ofEmerging microbes & infections · 2025
    Article
  6. Genetic determinants ofMicrobiology spectrum · 2025
    Article
  7. Article
  8. An additional proofreader contributes to DNA replication fidelity in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ming-Zhi Deng *Key Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0001-6586-6161
Qingyun Liu *Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.ORCID 0000-0002-2284-5050
Shu-Jun CuiKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Yi-Xin WangKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Guoliang ZhuShanghai Zelixir Biotech Company Ltd., Shanghai 200030, China.ORCID 0009-0008-1110-1479
Han FuKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Mingyu GanCenter for Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.ORCID 0009-0008-4405-092X
Yuan-Yuan XuKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0003-4744-2191
Xia CaiKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0003-2292-4194
Sheng WangShanghai Zelixir Biotech Company Ltd., Shanghai 200030, China.
Wei ShaShanghai Clinical Research Center for Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Shanghai 200433, China.
Guo-Ping ZhaoDepartment of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China.
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.
Liang-Dong LyuKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0001-6391-6030

Funding

Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2M
MOST | National Key Research and Development Program of China (NKPs) 2023YFC2307303MOST | National Natural Science Foundation of China (NSFC) 31800123MOST | National Natural Science Foundation of China (NSFC) 31830002MOST | National Natural Science Foundation of China (NSFC) 31970032MOST | National Natural Science Foundation of China (NSFC) 81991532MOST | National Natural Science Foundation of China (NSFC) 82372293NIAID NIH HHS P01 AI132130
6 · The paper itself

Abstract

The removal of mis-incorporated nucleotides by proofreading activity ensures DNA replication fidelity. Whereas the ε-exonuclease DnaQ is a well-established proofreader in the model organism

Indexed as

DNA ReplicationBacterial ProteinsDNA, BacterialMutationMycobacterium smegmatisMycobacterium tuberculosisBacterial ProteinsDNA, BacterialDnaQDNA replication fidelitydrug resistanceMycobacteriumproofreading

Identifiers

PMID39141351
PMCPMC11348249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.