Evidence map›Paper›PMID 39141271›Full record

ArticleJournal of autism and developmental disorders2025

Association of Irritability with Restricted, Repetitive Behaviors and Social Communication Challenges in Autistic Youth.

Michelle Menezes, Megan Rutten, Sydney Anderson, Jordan Linde, Karim Ibrahim, Denis G Sukhodolsky

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michelle MenezesChild Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA. michelle.menezes@yale.edu.ORCID http://orcid.org/0000-0003-0155-8367
Megan RuttenChild Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA.
Sydney AndersonChild Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA.
Jordan LindeChild Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA.
Karim IbrahimChild Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA.
Denis G SukhodolskyChild Study Center, Yale School of Medicine, 230 South Frontage Road, New Haven, CT, 06519, USA. denis.sukhodolsky@yale.edu.

Funding

Subnetwork-based Quantitative Imaging Biomarkers for Therapy Assessment in AutismR01NS035193 · NINDS · YALE UNIVERSITY · PI JAMES S DUNCAN, LAWRENCE H. STAIB · 1996 to 2026
$9.2M
Neural Mechanisms of CBT for Anxiety in Children with Autism Spectrum DisorderR01HD083881 · NICHD · YALE UNIVERSITY · PI PELPHREY, KEVIN A, SUKHODOLSKY, DENIS G · 2016 to 2020
$2.8M
Using CBT to examine circuitry of frustrative non-reward in aggressive childrenR01MH101514 · NIMH · YALE UNIVERSITY · PI PELPHREY, KEVIN A, SUKHODOLSKY, DENIS G · 2013 to 2016
$1.8M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD083881NICHD NIH HHS R01 HD083881NIMH NIH HHS L30 MH124229NIMH NIH HHS R01 MH101514NINDS NIH HHS R01 NS035193U.S. Department of Defense W81XWH2010718
6 · The paper itself

Abstract

Although affective irritability is a common and concerning problem for autistic youth, limited research has examined relations among core autism characteristics and irritability. Therefore, this study investigated potential associations among types of restricted/repetitive behaviors (RRBs) and social communication challenges and irritability in autistic children and adolescents. Participants were 107 autistic youth recruited from a university-based autism clinical research program. Two hierarchical multiple regressions were conducted with Affective Reactivity Index as the dependent variable. Covariates were entered at step 1, followed by the independent variables of interest at step 2. For the first model, independent variables of interest were Repetitive Behavior Scale-Revised subscales: stereotyped behavior, self-injurious behavior, compulsive behavior, ritualistic behavior, sameness behavior, and restricted behavior. For the second model, independent variables of interest were Social Responsiveness Scale, Second Edition subscales: social awareness, social cognitive, social communication, and social motivation. Irritability was significantly associated with several categories of RRBs (i.e., insistence on sameness, stereotypic behavior, and restricted interests/activities). Nonetheless, irritability was not associated with categories of social communication and interaction challenges in autistic youth. Results from this study indicated differing associations between core autism characteristics and affective irritability. Findings highlight the importance of differentiating types of restricted, repetitive behaviors and social communication and interaction challenges in conceptualizing mental health concerns in autistic youth.

Indexed as

Autism Spectrum DisorderAutistic DisorderCommunicationIrritable MoodSocial BehaviorSocial InteractionStereotyped BehaviorAdolescentChildFemaleHumansMaleSelf-Injurious BehaviorAutismIrritabilityRepetitive BehaviorsSocial Communication

Identifiers

PMID39141271
PMCPMC12959343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.