Evidence map›Paper›PMID 39141187›Full record

Observational studyObesity surgery2024

Nutrient Status and Supplement Use During Pregnancy Following Metabolic Bariatric Surgery: A Multicenter Observational Cohort Study.

Laura Heusschen, Agnes A M Berendsen, Arianne C van Bon, Judith O E H van Laar, Ineke Krabbendam, Eric J Hazebroek

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06796829 (Nutritional Status of Pregnant Women Following Bariatric Surgery), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06796829 completednot on this map

Nutritional Status of Pregnant Women Following Bariatric Surgery

Typeobservational_patient_registrySponsorRijnstate HospitalRan2018 to 2022Enrolled129ConditionsObesity and Obesity-related Medical Conditions, Pregnancy, Metabolic Surgery
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura HeusschenDivision of Human Nutrition and Health, Wageningen University, PO Box 17 6700 AA, Wageningen, The Netherlands. LHeusschen@Rijnstate.nl.ORCID 0000-0002-8096-0188
Agnes A M BerendsenDivision of Human Nutrition and Health, Wageningen University, PO Box 17 6700 AA, Wageningen, The Netherlands.
Arianne C van BonDepartment of Internal Medicine, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, The Netherlands.
Judith O E H van LaarDepartment of Obstetrics and Gynecology, Máxima Medical Center, PO Box 7777, 5500 MB, Veldhoven, The Netherlands.
Ineke KrabbendamDepartment of Obstetrics and Gynecology, Hospital Gelderse Vallei, PO Box 9025, 6710 HN, Ede, The Netherlands.
Eric J HazebroekDivision of Human Nutrition and Health, Wageningen University, PO Box 17 6700 AA, Wageningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPregnant women with a history of metabolic bariatric surgery (MBS) are at high risk of developing nutrient deficiencies, leading to greater challenges to reach nutritional requirements. This study compared nutrient status of women using specialized "weight loss surgery" multivitamin supplementation (WLS-MVS) to those using standard supplementation (sMVS) during pregnancy following MBS.

methodsMulticenter observational cohort study including 119 pregnant women at 41.0 (18.5-70.0) months after Roux-en-Y gastric bypass (RYGB, n = 80) or sleeve gastrectomy (SG, n = 39). Routine blood samples were analyzed every trimester (T1, T2, T3), and micronutrient serum levels were compared between WLS-MVS and sMVS users.

resultsDuring pregnancy after RYGB, WLS-MVS users demonstrated higher serum concentrations of hemoglobin (7.4 [7.2, 7.5] vs. 7.0 [6.8, 7.3] mmol/L), ferritin (23.2 [15.0, 35.7] vs. 13.7 [8.4, 22.4] µg/L), and folic acid (31.4 [28.7, 34.2] vs. 25.4 [21.3, 29.4] nmol/L) and lower serum vitamin B6 levels (T1: 90.6 [82.0, 99.8] vs. 132.1 [114.6, 152.4] nmol/L) compared to sMVS users. Iron deficiencies and elevated serum vitamin B6 levels were less prevalent in the WLS-MVS group. During pregnancy after SG, WLS-MVS users showed higher serum vitamin D concentrations (89.7 [77.6, 101.8] vs. 65.4 [53.3, 77.4] nmol/L) and lower serum vitamin B1 concentrations (T2: 137.4 [124.2, 150.6] vs. 161.6 [149.0, 174.1] nmol/L, T3: 133.9 [120.1, 147.7] vs. 154.7 [141.9, 167.5] nmol/L) compared to sMVS users.

conclusionLow maternal concentrations of micronutrients are highly prevalent during pregnancy after MBS. The use of specialized multivitamin supplementation generally resulted in higher serum levels during pregnancy compared to standard supplementation. Future research is needed to investigate how supplementation strategies can be optimized for this high-risk population.

Indexed as

Dietary SupplementsNutritional StatusObesity, MorbidPregnancy ComplicationsAdultBariatric SurgeryCohort StudiesFemaleFolic AcidGastrectomyGastric BypassHumansPregnancyVitaminsFolic AcidVitaminsDeficienciesMetabolic Bariatric SurgeryNutrient statusPregnancySupplementation

Identifiers

PMID39141187
PMCPMC11464611

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.