Evidence map›Paper›PMID 39141112›Full record

ArticleInternational urogynecology journal2024

Timing of Trial of Void After Radical Hysterectomy: Long-Term Urinary Outcomes at Two Academic Tertiary Care Institutions.

Julia K Shinnick, Alex Rosenthal, Jennifer Pearson, Rubin Raju, Alicia Youssef, Erin M Lips, Christina Raker, Matthew M Scarpaci, John Occhino, Gretchen Glaser and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International urogynecology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julia K ShinnickDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Women & Infants Hospital/Warren Alpert Medical School of Brown University, 101 Plain St, Ste 5, Providence, RI, 02905, USA. JShinnick@wihri.org.ORCID 0000-0001-8846-064X
Alex RosenthalDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, 02215, USA.
Jennifer PearsonDepartment of Obstetrics and Gynecology, Mayo Clinic Division of Urogynecology, 200 First Street SW, Rochester, MN, 55905, USA.
Rubin RajuDepartment of Obstetrics and Gynecology, Mayo Clinic Division of Urogynecology, 200 First Street SW, Rochester, MN, 55905, USA.
Alicia YoussefDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Women & Infants Hospital/Warren Alpert Medical School of Brown University, 101 Plain St, Ste 5, Providence, RI, 02905, USA.
Erin M LipsDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indiana University Health, 1030 W Michigan St, Indianapolis, IN, 46202, USA.
Christina RakerDivision of Research, Department of Obstetrics and Gynecology, Lifespan Hospital/Warren Alpert Medical School of Brown University, Providence, RI, 02905, USA.
Matthew M ScarpaciHassenfeld Institute of Brown University, Providence, RI, 02905, USA.
John OcchinoDepartment of Obstetrics and Gynecology, Mayo Clinic Division of Urogynecology, 200 First Street SW, Rochester, MN, 55905, USA.
Gretchen GlaserDepartment of Obstetrics and Gynecology, Mayo Clinic Division of Gynecologic Oncology, 200 First Street SW, Rochester, MN, 55905, USA.
Kyle WohlrabDivision of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Women & Infants Hospital/Warren Alpert Medical School of Brown University, 101 Plain St, Ste 5, Providence, RI, 02905, USA.
Katina RobisonDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, MA, 02111, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisMany patients develop bladder symptoms after radical hysterectomy. This study compared urinary outcomes following radical hysterectomy based on trial of void (TOV) timing (pre-discharge TOV versus post-discharge TOV).

methodsA retrospective non-inferiority study of patients at two academic tertiary referral centers who underwent radical hysterectomy between January 2010 and January 2020 was carried out. Patients were stratified according to timing of postoperative TOV: either pre-discharge or post-discharge from the hospital. Short-term urinary outcomes (including passing TOV, representation with retention) and long-term de novo urinary dysfunction (defined as irritative voiding symptoms, urgency, frequency, nocturia, stress or urgency incontinence, neurogenic bladder, and/or urinary retention) were extracted from the medical record. We hypothesized that the proportion of patients who failed pre-discharge TOV would be within a 15% non-inferiority margin of post-discharge TOV.

resultsA total of 198 patients underwent radical hysterectomy for cervical (118 out of 198; 59.6%), uterine (36 out of 198; 18.2%), and ovarian (29 out of 198; 14.6%) cancer. One hundred and nineteen patients (119 out of 198, 60.1%) underwent pre-discharge TOV, of whom 14 out of 119 (11.8%) failed. Of the post-discharge TOV patients (79 out of 198, 39.9%), 5 out of 79 (6.3%) failed. The proportion of patients who failed a pre-discharge TOV was within the non-inferiority margin (5.4% difference, p = 0.23). A greater proportion of patients in the post-discharge TOV group developed long-term de novo urinary dysfunction (27.2% difference, p = 0.005). Median time to diagnosis of de novo urinary dysfunction was 0.5 years (range 0-9) in the pre-discharge TOV group versus 1.0 year (range 0-6) in the post-discharge TOV group (p > 0.05).

conclusionsIn this study, pre-discharge TOV had non-inferior short-term outcomes and improved long-term outcomes.

Indexed as

HysterectomyPostoperative ComplicationsTertiary Care CentersAdultAgedFemaleHumansMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeUrinationNeurogenic bladderRadical hysterectomyTrial of voidUrinary incontinenceUrinary retention

Identifiers

PMID39141112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.