Evidence map›Paper›PMID 39141107›Full record

ArticleJournal of gastroenterology2024

Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis.

Ying Zhang, Weiyi Shen, Zhehang Chen, Jiamin He, Lijun Feng, Lan Wang, Shujie Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. [HeZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying Zhang *Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Weiyi Shen *Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhehang Chen *Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jiamin HeDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lijun FengDepartment of Nutriology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lan WangDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. 3410001@zju.edu.cn.
Shujie ChenDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. chenshujie77@zju.edu.cn.ORCID http://orcid.org/0000-0001-9523-0033

Funding

National Natural Science Foundation of China 82270573National Natural Science Foundation of China 82303271Zhejiang Provincial Medical and Health Science and Technology Project 2023KY785Zhejiang Provincial Science and Technology Project 2022C03145
6 · The paper itself

Abstract

backgroundThe intake of high-fructose corn syrup (HFCS) may increase the risk of colorectal cancer (CRC). This study aimed to explore the potential effects and mechanisms of resistant starch (RS) in HFCS-induced colon tumorigenesis.

methodsThe azoxymethane/dextran sodium sulfate (AOM/DSS) and Apc

resultsRS suppressed HFCS-induced colon tumorigenesis through reshaping the microbial community. Mechanistically, the alteration of the microbial community after RS supplement increased the levels of intestinal SCFAs, especially butyrate, leading to the suppression of glycolysis and CRC cell proliferation by downregulating HK2.

conclusionsOur study identified RS as a candidate of protective factors in CRC and may provide a potential target for HFCS-related CRC treatment.

Indexed as

CarcinogenesisCell ProliferationColonic NeoplasmsFatty Acids, VolatileGlycolysisHexokinaseHigh Fructose Corn SyrupResistant StarchAnimalsAzoxymethaneColorectal NeoplasmsDextran SulfateDisease Models, AnimalDown-RegulationGastrointestinal MicrobiomeHumansAzoxymethaneDextran SulfateFatty Acids, VolatileHexokinaseHigh Fructose Corn SyrupHK2 protein, humanResistant StarchColorectal cancerGlycolysisGut microbiotaHigh-fructose corn syrupResistant starch

Identifiers

PMID39141107
PMCPMC11415400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.