Evidence map›Paper›PMID 39141056›Full record

ReviewCell and tissue research2024

Autophagy accompanying the developmental process of male germline stem cells.

Zhuofei Jiang, Liji Chen, Tao Wang, Jie Zhao, Shuxian Liu, Yating He, Liyun Wang, Hongfu Wu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell and tissue research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhuofei Jiang *Department of Gynecology, Foshan Woman and Children Hospital, Foshan, China.
Liji Chen *Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
Tao Wang *Department of Surgery, Longjiang Hospital of Shunde District, Foshan, China.
Jie ZhaoDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
Shuxian LiuDepartment of Science and Education, Guangzhou Huadu District Maternal and Child Health Care Hospital (Huzhong Hospital of Huadu District), Guangzhou, China.
Yating HeDepartment of Obstetrics, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, China.
Liyun WangDepartment of Reproductive Medicine, Guangzhou Huadu District Maternal and Child Health Care Hospital (Huzhong Hospital of Huadu District), Guangzhou, China. wangliyun.9222@163.com.
Hongfu WuDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China. hongfuw@126.com.ORCID http://orcid.org/0000-0002-1115-3681

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515140184College Students Innovative Experimental Project in Guangdong Medical University FZDB005College Students Innovative Experimental Project in Guangdong Medical University ZYDS002College Students Innovative Experimental Project in Guangdong Medical University ZZDC001College Students Innovative Experimental Project in Guangdong Medical University ZZDI001College Students' Science and Technology Innovation Training Project 202210571025College Students' Science and Technology Innovation Training Project 202210571030College Students' Science and Technology Innovation Training Project S202210571087College Students' Science and Technology Innovation Training Project S202210571097Guangzhou Huadu District Basic and Applied Basic District and Hospital Joint Funding Project 23HDQYLH26Medical Science and Technology Foundation of Guangdong Province A2020353Medical Science and Technology Foundation of Guangdong Province A2023235National Natural Science Foundation of China 82071374Talent Development Foundation of The First Dongguan Affiliated Hospital of Guangdong Medical University PF100-1-01、PF100-1-04
6 · The paper itself

Abstract

Germline stem cells are a crucial type of stem cell that can stably pass on genetic information to the next generation, providing the necessary foundation for the reproduction and survival of organisms. Male mammalian germline stem cells are unique cell types that include primordial germ cells and spermatogonial stem cells. They can differentiate into germ cells, such as sperm and eggs, thereby facilitating offspring reproduction. In addition, they continuously generate stem cells through self-renewal mechanisms to support the normal function of the reproductive system. Autophagy involves the use of lysosomes to degrade proteins and organelles that are regulated by relevant genes. This process plays an important role in maintaining the homeostasis of germline stem cells and the synthesis, degradation, and recycling of germline stem cell products. Recently, the developmental regulatory mechanism of germline stem cells has been further elucidated, and autophagy has been shown to be involved in the regulation of self-renewal and differentiation of germline stem cells. In this review, we introduce autophagy accompanying the development of germline stem cells, focusing on the autophagy process accompanying the development of male spermatogonial stem cells and the roles of related genes and proteins. We also briefly outline the effects of autophagy dysfunction on germline stem cells and reproduction.

Indexed as

AutophagyStem CellsAnimalsCell DifferentiationGerm CellsHumansMaleAutophagyDifferentiationGermline stem cellsSelf-renewalSpermatogonial stem cells

Identifiers

PMID39141056

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.