Evidence map›Paper›PMID 39141020›Full record

SynthesisInternational ophthalmology2024

Relationship between CCL2 gene 2518A/G (rs1024611) polymorphism and age-related macular degeneration susceptibility: meta-analysis and trial sequential analysis.

Haokun Tian, Weikai Xu, Lequan Wen, Tiangang Song, Ye Tian, Lirui Tang, Nan Guo, Qianxi Chen, Haoran Wang, Kaiyuan Zhang and 2 more

Abstract readMeta-AnalysisReview
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In one paragraph

Synthesis in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haokun TianJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Weikai XuJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Lequan WenJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Tiangang SongJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Ye TianJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Lirui TangJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Nan GuoThe Third Affiliated Hospital of Nanchang University, Nanchang, China.
Qianxi ChenJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Haoran WangJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Kaiyuan ZhangCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Xinyuan ZhangJoint Programme of Nanchang University and Queen Mary University of London, Nanchang University, Nanchang, China.
Yu PengDepartment of Ophthalmology, First Affiliated Hospital of Nanchang University, Nanchang, China. pengyu0711@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the association between the CC-cytokine ligand-2 (CCL2) 2518A/G (rs1024611) single nucleotide polymorphism (SNP) and susceptibility to age-related macular degeneration (AMD).

methodsPubMed, Embase, Web of Science, and other databases were searched for articles published before August 24, 2023. After searching, data extraction, and quality assessment, meta-analysis and trial sequential analysis were conducted using RevMan 5.4, Stata 17.0, and TSA 0.9.5.10 Beta software. Combined OR, P values, and 95% confidence intervals (CIs) were calculated. Sensitivity analysis, subgroup analysis and publication bias assessment were also performed.

resultsSix articles, comprising 1186 cases and 1124 controls, were included. No significant statistical difference was found in six main outcomes. However, due to observed heterogeneity and high sensitivity, subgroup analysis was performed, revealing statistically significant differences across different regions. No significant publication bias was observed. Trial sequential analysis suggested the need for additional follow-up case-control studies to further validate the findings.

conclusionThe CCL2 gene 2518A/G (rs1024611) polymorphism is associated with AMD susceptibility. Among Caucasian populations in West Asia and Europe, the G allele is protective against AMD, whereas in East and South Asia, it poses a risk factor.

Indexed as

Chemokine CCL2Genetic Predisposition to DiseaseMacular DegenerationPolymorphism, Single NucleotideHumansCCL2 protein, humanChemokine CCL2Age-related macular degenerationCCL2Meta-analysisrs1024611Single nucleotide polymorphismTrial sequential analysis

Identifiers

PMID39141020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.