Evidence map›Paper›PMID 39141017›Full record

ArticlePsychological science2024

Intervening After Trauma: Child-Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration.

Alexandra D W Sullivan, Sarah M Merrill, Chaini Konwar, Michael Coccia, Luisa Rivera, Julia L MacIsaac, Alicia F Lieberman, Michael S Kobor, Nicole R Bush

Abstract read
In one paragraph

Article in Psychological science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Practitioner Review: Infant mental health meets cell and molecular biology - a look to the future.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Review
  4. Epigenetic Clocks: An emerging role for Biomarkers of Aging in Psychiatry.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandra D W SullivanDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco.ORCID 0000-0003-4513-9578
Sarah M MerrillBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Chaini KonwarBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Michael CocciaDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco.
Luisa RiveraNeukom Institute for Computational Science, Dartmouth College.
Julia L MacIsaacBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Alicia F LiebermanDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco.
Michael S KoborBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Preventing Inter-generational Transmission of Obesity and Cardiometabolic RiskR01HL116511 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUSH, NICOLE RENEE · 2013 to 2017
$3.1M
NCATS NIH HHS UL1 TR000004NHLBI NIH HHS R01 HL116511
6 · The paper itself

Abstract

Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child-parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (

Indexed as

Epigenesis, GeneticAdverse Childhood ExperiencesChildChild, PreschoolFemaleHumansMaleParent-Child RelationsParentsPsychotherapychildhood traumachild–parent psychotherapyepigenetic ageinterventionPedBE

Identifiers

PMID39141017
PMCPMC13614526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.