Evidence map›Paper›PMID 39141004›Full record

ArticleACS nano2024

Soft, Multifunctional MXene-Coated Fiber Microelectrodes for Biointerfacing.

Lingyi Bi, Raghav Garg, Natalia Noriega, Ruocun John Wang, Hyunho Kim, Kseniia Vorotilo, Justin C Burrell, Christopher E Shuck, Flavia Vitale, Bhavik Anil Patel and 1 more

Abstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Design, Construction, and Application of Implantable Fiber Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  2. Review
  3. Size Scaling of the Electrochemical Performance of TiSmall (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Size Scaling of the Electrochemical Performance of TibioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. The Future of MXene Fibers.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingyi BiDepartment of Materials Science and Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-3486-1549
Raghav GargDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-3501-6892
Natalia NoriegaSchool of Applied Sciences, University of Brighton, Brighton BN2 4AT, U.K.
Ruocun John WangDepartment of Materials Science and Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-8095-5285
Hyunho KimDepartment of Materials Science and Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-2381-9716
Kseniia VorotiloDepartment of Materials Science and Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.
Justin C BurrellDepartment of Oral and Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-5361-9224
Christopher E ShuckDepartment of Materials Science and Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-1274-8484
Flavia VitaleDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Bhavik Anil PatelSchool of Applied Sciences, University of Brighton, Brighton BN2 4AT, U.K.ORCID 0000-0002-8773-3850
Yury GogotsiDepartment of Materials Science and Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-9423-4032

Funding

Validating MXene Electrodes for Next-Generation ElectroencephalographyR01NS121219 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MEDAGLIA, JOHN, VITALE, FLAVIA · 2021 to 2025
$2.3M
Advanced Training at the Interface of Engineering and Oral-Craniofacial SciencesT90DE030854 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI Hyun Koo, Kathleen J Stebe · 2021 to 2026
$1.4M
NIDCR NIH HHS T90 DE030854NINDS NIH HHS R01 NS121219
6 · The paper itself

Abstract

Flexible fiber-based microelectrodes allow safe and chronic investigation and modulation of electrically active cells and tissues. Compared to planar electrodes, they enhance targeting precision while minimizing side effects from the device-tissue mechanical mismatch. However, the current manufacturing methods face scalability, reproducibility, and handling challenges, hindering large-scale deployment. Furthermore, only a few designs can record electrical and biochemical signals necessary for understanding and interacting with complex biological systems. In this study, we present a method that utilizes the electrical conductivity and easy processability of MXenes, a diverse family of two-dimensional nanomaterials, to apply a thin layer of MXene coating continuously to commercial nylon filaments (30-300 μm in diameter) at a rapid speed (up to 15 mm/s), achieving a linear resistance below 10 Ω/cm. The MXene-coated filaments are then batch-processed into free-standing fiber microelectrodes with excellent flexibility, durability, and consistent performance even when knotted. We demonstrate the electrochemical properties of these fiber electrodes and their hydrogen peroxide (H

Indexed as

Hydrogen PeroxideMicroelectrodesAnimalsElectric ConductivityElectrochemical TechniquesNanostructuresRatsUrinary BladderHydrogen Peroxidechemical sensingdip coatingelectrical sensingfiber electrodeMXeneneural stimulation

Identifiers

PMID39141004
PMCPMC11363215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.