Evidence map›Paper›PMID 39140798›Full record

ArticleBiomaterials science2024

Varying the hydrophobic core composition of polymeric nanoparticles affects NLRP3 inflammasome activation.

Mehak Malhotra, Dhruv Chotaliya, Maharshi Debnath, Ruchi Patel, Ashish Kulkarni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Toward targeting of inflammasome signaling in venous thrombosis.Journal of thrombosis and haemostasis : JTH · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mehak MalhotraDepartment of Chemical Engineering, University of Massachusetts, Amherst, MA 01003, USA. akulkarni@engin.umass.edu.
Dhruv ChotaliyaDepartment of Chemical Engineering, University of Massachusetts, Amherst, MA 01003, USA. akulkarni@engin.umass.edu.
Maharshi DebnathDepartment of Chemical Engineering, University of Massachusetts, Amherst, MA 01003, USA. akulkarni@engin.umass.edu.
Ruchi PatelDepartment of Pathology, UMass Chan Medical School-Baystate, Springfield, MA 01107, USA.
Ashish KulkarniDepartment of Chemical Engineering, University of Massachusetts, Amherst, MA 01003, USA. akulkarni@engin.umass.edu.ORCID http://orcid.org/0000-0002-5713-2202

Funding

Polymeric Nanomaterials for Probing and Modulating Innate Immune ResponsesR35GM147019 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Ashish A. Kulkarni · 2022 to 2026
$2.0M
Transmission Electron Microscope for Core EM FacilityS10OD025113 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENDRICKS, GREGORY · 2018 to 2018
$600k
NIGMS NIH HHS R35 GM147019NIH HHS S10 OD025113
6 · The paper itself

Abstract

Understanding the interactions of nanoparticle carriers with innate immune cells is crucial for informing the design and efficacy of future nano-immunotherapies. An intriguing aspect of their interaction with the immune system has recently emerged,

Indexed as

Hydrophobic and Hydrophilic InteractionsInflammasomesNanoparticlesNLR Family, Pyrin Domain-Containing 3 ProteinPolymersAnimalsHumansMacrophagesMiceMice, Inbred C57BLReactive Oxygen SpeciesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePolymersReactive Oxygen Species

Identifiers

PMID39140798
PMCPMC12883076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.