Observational studyUnited European gastroenterology journal2024
Global trends in opioid use for pain management in acute pancreatitis: A multicentre prospective observational study.
Observational study in United European gastroenterology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European Interdisciplinary Guidelines on Pain Management in Acute Pancreatitis: UEG, EPC, EDS, ESDO, EAGEN, ESPGHAN, ESGAR, and ESPCG Evidence-Based Recommendations.United European gastroenterology journal · 2026Guideline
- Naldemedine for the Prevention of Recurrent Acute Pancreatitis: A Randomised, Double-Blind, Placebo-Controlled Trial.United European gastroenterology journal · 2026Trial
- Pain characteristics and multimodal analgesia in children hospitalised with pancreatitis: A retrospective study from a tertiary paediatric centre in India.Indian journal of anaesthesia · 2026Article
- Gut microbiota predict development of postdischarge diabetes mellitus in acute pancreatitis.Gut · 2026Article
- High Serum Lipase Level is Associated With Increased Analgesic Use in Hospitalized Patients With Acute Pancreatitis.Pain research & management · 2026Article
- Optimising Pain Relief in Acute Pancreatitis: An Evidence-Based Approach.Journal of clinical medicine · 2025Review
- The Effect of Dexmedetomidine on Mortality in Patients with Acute Pancreatitis: A Retrospective Propensity Score Matching Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Pain intensity and prognosis of acute pancreatitis in an international, prospective study.The British journal of surgery · 2025Article
- Extracellular vesicle therapy for acute pancreatitis: experimental validation of mesenchymal stem cell-derived nanovesicles.BMC pharmacology & toxicology · 2025Article
- Increased Early Post-Discharge Mortality in Patients With Acute Pancreatitis.United European gastroenterology journal · 2025Article
- [Pancreatitis from drugs-Drugs for treatment of pancreatitis].Innere Medizin (Heidelberg, Germany) · 2025Review
- Differences in the burden of pediatric pancreatitis across countries and regions: One size does not fit all.United European gastroenterology journal · 2025Article
- Guidelines towards comprehensive care in acute pancreatitis.Hepatobiliary surgery and nutrition · 2024Article
- Global trends in opioid use for pain management in acute pancreatitis: A multicentre prospective observational study.United European gastroenterology journal · 2024Observational
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundSince there is no current international consensus on the optimal approach for pain management in acute pancreatitis (AP), analgesic practices may vary across different healthcare settings.
objectiveThis study explored global disparities in analgesic use, in particular opioids, during admission and at discharge in hospitalised AP patients.
methodsThis was a post hoc analysis of the prospective PAINAP database, which included all admissions for AP between April and June 2022 with a 1-month follow-up. Demographic details, analgesic use, and clinical outcomes were recorded during admission and at discharge. Odds ratios (ORs) for opioid use during admission and at discharge were identified using multivariable regression analyses.
resultsAmongst the 1864 patients (52% males, median age 56 (interquartile range, 41-71)) across three different continents, simple analgesics were predominantly used as the primary analgesic (70%). Opioid use during admission was lowest in European centres (67%). Admission in Asian (OR, 2.53 (95% confidence interval (CI), 1.59-4.04), p < 0.001), and Australian (OR, 5.81 (95% CI, 3.19-10.56), p < 0.001) centres was associated with opioid administration during admission compared with European centres. Increased pain severity, longer pre-admission pain duration, organ failure, and longer length of admission increased opioid use during admission. At discharge, Asian (OR, 2.01 (95% CI, 1.40-2.88), p < 0.001) and Australian (OR, 1.91 (95% CI, 1.28-2.85), p = 0.002) centres were associated with opioid prescription compared with European centres. Increased pain severity, longer pre-admission pain duration, acute necrotic collections, and walled-off necrosis also increased the likelihood of opioid prescription at discharge.
conclusionThere are substantial intercontinental differences in opioid use for AP pain. Accordingly, there is a need for international guidelines on pain management in AP.
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