ArticleJournal of psychopharmacology (Oxford, England)2024
Regular cannabis use modulates gamma activity in brain regions serving motor control.
Article in Journal of psychopharmacology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults.GeroScience · 2026Article
- Marijuana use and its association with unhealthy weight control and muscle-enhancing behaviors among sexual minority men in the United States: a cross-sectional analysis.Journal of cannabis research · 2026Article
- Neurochemical changes in GABA+, Glx, and the excitatory/inhibitory ratio in the calcarine cortex with healthy aging.NeuroImage · 2025Article
- Regular cannabis use modulates gamma functional connectivity with V1 during visual processing.NeuroImage · 2025Article
- Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Altered Functional Connectivity Dynamics Serving Cognitive Flexibility in Regular Cannabis Users.Addiction biology · 2025Article
- Cannabis- and HIV-related perturbations to the cortical gamma dynamics supporting inhibitory processing.Brain communications · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPeople who regularly use cannabis exhibit altered brain dynamics during cognitive control tasks, though the impact of regular cannabis use on the neural dynamics serving motor control remains less understood.
aimsWe sought to investigate how regular cannabis use modulates the neural dynamics serving motor control.
methodsThirty-four people who regularly use cannabis (cannabis+) and 33 nonusers (cannabis-) underwent structured interviews about their substance use history and performed the Eriksen flanker task to map the neural dynamics serving motor control during high-density magnetoencephalography (MEG). The resulting neural data were transformed into the time-frequency domain to examine oscillatory activity and were imaged using a beamforming approach.
resultsMEG sensor-level analyses revealed robust beta (16-24 Hz) and gamma oscillations (66-74 Hz) during motor planning and execution, which were imaged using a beamformer. Both responses peaked in the left primary motor cortex and voxel time series were extracted to evaluate the spontaneous and oscillatory dynamics. Our key findings indicated that the cannabis+ group exhibited weaker spontaneous gamma activity in the left primary motor cortex relative to the cannabis- group, which scaled with cannabis use and behavioral metrics. Interestingly, regular cannabis use was not associated with differences in oscillatory beta and gamma activity, and there were no group differences in spontaneous beta activity.
conclusionsOur findings suggest that regular cannabis use is associated with suppressed spontaneous gamma activity in the left primary motor cortex, which scales with the degree of cannabis use disorder symptomatology and is coupled to behavioral task performance.
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