Evidence map›Paper›PMID 39140105›Full record

ArticleFrontiers in psychiatry2024

Major depressive disorder elevates the risk of dentofacial deformity: a bidirectional two-sample Mendelian randomization study.

Jinhan Nie, Yi Zhang, Jun Ma, Qing Xue, Min Hu, Huichuan Qi

Abstract read
In one paragraph

Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinhan NieDepartment of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Yi ZhangDepartment of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Jun MaDepartment of Oral Anatomy and Physiology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Qing XueDepartment of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Min HuDepartment of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Huichuan QiDepartment of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The association between psychiatric disorders and dentofacial deformities has attracted widespread attention. However, their relationship is currently unclear and controversial. Methods: A two-sample bidirectional MR analysis was performed to study the causal relationship between dentofacial deformity and eight psychiatric disorders, including major depressive disorder, panic disorder, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, Alzheimer's disease, autism spectrum disorder, and neuroticism. Inverse variance weighted, weighted median, MR-Egger regression, weighted mode four methods, and further sensitivity analyses were conducted. Results: The major depressive disorder affected dentofacial deformity, with an OR = 1.387 (95% CI = 1.181-1.629, Conclusions: Major depressive disorder might elevate the risk of dentofacial deformities, and dentofacial deformity conditions would increase the risk of the incidence of neuroticism.

Indexed as

causal relationshipdentofacial deformitymajor depressive disorderMendelian randomizationpsychiatric disorders

Identifiers

PMID39140105
PMCPMC11319251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.