Evidence map›Paper›PMID 39140067›Full record

ArticleACS medicinal chemistry letters2024

Systematical Mutational Analysis of FRATtide against Osteoclast Differentiation by Alanine Scanning.

Yi Yang, Chenchen Geng, Huaxing Shen, Jingru Chao, Zhe Wang, Wei Cong, Xiang Li, Guangming Ye, Yunyun Jiang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yi YangSchool of Pharmacy, Anhui Medical University, HeFei 230032, China.
Chenchen GengSchool of Pharmacy, Anhui Medical University, HeFei 230032, China.
Huaxing ShenSchool of Medicine, Shanghai University, Shanghai 200444, China.
Jingru ChaoSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Zhe WangInstitute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Wei CongSchool of Medicine, Shanghai University, Shanghai 200444, China.
Xiang LiSchool of Pharmacy, Second Military Medical University, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-1098-7713
Guangming YeXinrui Hospital, Xinwu District, Wuxi, 214000, China.
Yunyun JiangHospital 904, Wuxi, 214000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis, a global bone disease, results in decreased bone density, mass, and microarchitecture deterioration, increasing fracture risk. In previous research, FRATtide, a peptide derived from a glycogen synthase kinase-3 binding protein, effectively hindered osteoclast differentiation to yield therapeutically potent derivatives via single and double stapling. However, FRATtide's structure-activity relationship remains unclear. This study synthesized 25 FRATtide-derived peptides through systematic alanine scanning and evaluated their activities. Substitutions in Pro

Identifiers

PMID39140067
PMCPMC11318000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.