Evidence map›Paper›PMID 39140042›Full record

ArticleACS medicinal chemistry letters2024

TRPA1 Inhibition Effects by 3-Phenylcoumarin Derivatives.

Carita Sallomy, Paul Awolade, Minna Rahnasto-Rilla, Mari Hämäläinen, Liisa P Nousiainen, Niklas G Johansson, Sanna Hiltunen, Petri Turhanen, Eeva Moilanen, Maija Lahtela-Kakkonen and 1 more

Abstract read
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In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carita SallomySchool of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.
Paul AwoladeSchool of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban 4041, South Africa.ORCID https://orcid.org/0000-0003-3995-121X
Minna Rahnasto-RillaSchool of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.ORCID https://orcid.org/0000-0002-8882-747X
Mari HämäläinenFaculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere 33520, Finland.
Liisa P NousiainenInstitute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Niklas G JohanssonDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.ORCID https://orcid.org/0000-0002-8226-4813
Sanna HiltunenSchool of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.
Petri TurhanenSchool of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.ORCID https://orcid.org/0000-0002-7546-8906
Eeva MoilanenFaculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere 33520, Finland.ORCID https://orcid.org/0000-0002-8577-0316
Maija Lahtela-KakkonenSchool of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.ORCID https://orcid.org/0000-0001-7163-7728
Juri M TimonenSchool of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland.ORCID https://orcid.org/0000-0001-7720-2215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient receptor potential ankyrin 1 (TRPA1) protein plays an important role in the inflammatory response, and it has been associated with different pain conditions and pain-related diseases, making TRPA1 a valid target for painkillers. In this study, we identified potential TRPA1 inhibitors and located their binding sites utilizing computer-aided drug design (CADD) techniques. The designed 3-phenylcoumarin-based TRPA1 inhibitors were successfully synthesized using a microwave assisted synthetic strategy. 3-(3-Bromophenyl)-7-acetoxycoumarin (

Identifiers

PMID39140042
PMCPMC11318103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.