Evidence map›Paper›PMID 39140038›Full record

ArticleACS medicinal chemistry letters2024

Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket.

Sjors van Klaveren, Mujtaba Hassan, Maria Håkansson, Richard E Johnsson, Jessica Larsson, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Tihomir Tomašič, Ulf J Nilsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sjors van KlaverenDepartment of Chemistry, Faculty of Science, Lund University, Naturvetarvägen 14, 223 62, Lund, Sweden.
Mujtaba HassanDepartment of Chemistry, Faculty of Science, Lund University, Naturvetarvägen 14, 223 62, Lund, Sweden.ORCID https://orcid.org/0000-0002-3187-0629
Maria HåkanssonSARomics Biostructures AB, Medicon Village, SE-223 81, Lund, Sweden.
Richard E JohnssonRed Glead Discovery AB, Medicon Village, SE-223 81, Lund, Sweden.
Jessica LarssonRed Glead Discovery AB, Medicon Village, SE-223 81, Lund, Sweden.
Žiga JakopinPharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-9384-0858
Marko AnderluhPharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0003-1768-8246
Hakon LefflerDepartment of Laboratory Medicine, Section MIG, Lund University, BMC-C1228b, Klinikgatan 28, 221 84, Lund, Sweden.ORCID https://orcid.org/0000-0003-4482-8945
Tihomir TomašičPharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-5534-209X
Ulf J NilssonDepartment of Chemistry, Faculty of Science, Lund University, Naturvetarvägen 14, 223 62, Lund, Sweden.ORCID https://orcid.org/0000-0001-5815-9522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Galectin-8 contains two different carbohydrate recognition domains (CRDs). Selective inhibitors for at least one CRD are desirable for galectin-8 biology studies and potentially for pharmacological purposes. Structure-guided design led to the discovery of potent and selective glycomimetic-heterocycle hybrid ligands, with a 4-(

Identifiers

PMID39140038
PMCPMC11318003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.