Evidence map›Paper›PMID 39139619›Full record

ArticleClinical case reports2024

Successful immunosuppressive drug-free immune tolerance induction in hemophilia B with inhibitor and anaphylaxis to factor IX: A case report.

Ángeles Palomo Bravo, Rosario Prieto Bonilla, Daniel Bardan Rebollar, Francisco José López-Jaime, Ihosvany Fernández-Bello

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ángeles Palomo BravoHematology Service Hospital Regional Universitario Materno-Infantil de Málaga Málaga Spain.
Rosario Prieto BonillaHematology Service Hospital Regional Universitario Materno-Infantil de Málaga Málaga Spain.
Daniel Bardan RebollarHematology Service Hospital Regional Universitario Materno-Infantil de Málaga Málaga Spain.
Francisco José López-JaimeThrombosis and Hemostasis Unit, Hematology Service Hospital Regional Universitario de Málaga Málaga Spain.
Ihosvany Fernández-BelloThrombosis and Hemostasis Unit, Hematology Service Hospital Regional Universitario de Málaga Málaga Spain.ORCID https://orcid.org/0000-0001-7822-8900

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recommendations advise factor IX desensitization before immune tolerance induction in severe hemophilia B, supported by immunosuppression. A child with inhibitor and anaphylaxis to factor IX showed successful immunosuppression-free immune tolerance induction using very low and slowly increasing doses of a factor IX extended-half-life product. Immune tolerance to factor IX based on this protocol merits further study.

Indexed as

anaphylaxis reactiondesensitization protocolfactor IX‐extended half‐life productimmune tolerance inductioninhibitorssevere hemophilia B

Identifiers

PMID39139619
PMCPMC11319222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.