ArticleFrontiers in microbiology2024
Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in
Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- CRISPR-activation reveals key resistance genes and vulnerabilities of copy number variants inbioRxiv : the preprint server for biology · 2026Article
- Azole-Driven Cross-Resistance and Transporter Gene Expression inMicroorganisms · 2026Article
- Species Identification, Virulence Factors, and Antifungal Resistance in ClinicalMicroorganisms · 2026Article
- Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance inFrontiers in microbiology · 2025Article
- Understanding adaptation to fluconazole: comparative insights into tolerance and resistance inFrontiers in cellular and infection microbiology · 2025Article
- Caspofungin paradoxical growth inFrontiers in cellular and infection microbiology · 2025Article
- Dual adaptive strategies inFrontiers in microbiology · 2025Article
- Antifungal activity and mechanism ofFrontiers in microbiology · 2025Article
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Authors and funding
4 authors.
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Abstract
Background: The emergence of tolerance to antifungal agents in Objective: This study aims to elucidate the genetic and molecular basis of ketoconazole tolerance in Methods: The wild-type Results: Adaptors exhibited tolerance to ketoconazole concentrations up to 16 μg/mL, a significant increase from the parent strain's inhibition at 0.015 μg/mL. All tolerant adaptors showed amplification of chromosome R, with 29 adaptors having trisomy and one having tetrasomy. This aneuploidy was unstable, reverting to euploidy and losing tolerance in drug-free conditions. Both Hsp90 and calcineurin were essential for maintaining and developing ketoconazole tolerance. Inhibition of these proteins resulted in loss of tolerance. The efflux gene Conclusion: Ketoconazole tolerance in
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