Evidence map›Paper›PMID 39139279›Full record

ArticleNIHR open research2023

Determining the optimal diagnostic and risk stratification approaches for people with hypertension in two rural populations in Kenya and The Gambia: a study protocol for IHCoR-Africa Work Package 2.

Alexander D Perkins, Juliet Otieno Awori, Modou Jobe, Ruth K Lucinde, Meike Siemonsma, Robinson Oyando, David A Leon, Emily Herrett, Andrew M Prentice, Anoop Sv Shah and 3 more

Abstract read
In one paragraph

Article in NIHR open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexander D Perkins *Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.ORCID https://orcid.org/0000-0002-9817-2390
Juliet Otieno Awori *Department of Epidemiology and Demography, KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.
Modou Jobe *Medical Research Council Unit The Gambia at LSHTM, Banjul, The Gambia.ORCID https://orcid.org/0000-0001-5309-5611
Ruth K LucindeDepartment of Epidemiology and Demography, KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-6926-8556
Meike SiemonsmaMedical Research Council Unit The Gambia at LSHTM, Banjul, The Gambia.
Robinson OyandoHealth Economics Research Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.
David A LeonDepartment of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Emily HerrettDepartment of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Andrew M PrenticeMedical Research Council Unit The Gambia at LSHTM, Banjul, The Gambia.
Anoop Sv ShahDepartment of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Pablo PerelDepartment of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Anthony EtyangDepartment of Epidemiology and Demography, KEMRI Wellcome Trust Research Programme, Kilifi, Kenya.
IHCoR-Africa Collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sub-Saharan Africa (SSA) has one of the highest prevalences of hypertension worldwide. The impact of hypertension is of particular concern in rural SSA, where access to clinics and hospitals is limited. Improvements in the management of people with hypertension in rural SSA could be achieved by sharing diagnosis and care tasks between the clinic and the community. To develop such a community-centred programme we need optimal approaches to identify and risk stratify patients with elevated blood pressure. The aim of the study is to improve the evidence base for diagnosis and risk estimation for a community-centred hypertension programme in two rural settings in SSA. Methods: We will conduct a cross-sectional study of 1250 adult participants in Kilifi, Kenya and Kiang West, The Gambia. The study has five objectives which will determine the: (1) accuracy of three blood pressure (BP) measurement methods performed by community health workers in identifying people with hypertension in rural SSA, compared to the reference standard method; (2) relationship between systolic BP and cardiovascular risk factors; (3) prevalence of hypertension-mediated organ damage (HMOD); (4) accuracy of innovative point-of-care (POC) technologies to identify patients with HMOD; and (5) cost-effectiveness of different combinations of BP and HMOD measurements for directing hypertension treatment initiation. Expected findings: This study will determine the accuracy of three methods for community BP measurement and POC technologies for HMOD assessment. Using the optimal methods in this setting it will estimate the prevalence of hypertension and provide the best estimate to date of HMOD prevalence in SSA populations. The cost-effectiveness of decision-making approaches for initiating treatment of hypertension will be modelled. These results will inform the development of a community-centred programme to improve care for hypertensive patients living in rural SSA. Existing community engagement networks will be used to disseminated within the research setting.

Indexed as

Blood pressureCommunityHypertensionHypertension mediated organ damageKenyaThe Gambia

Identifiers

PMID39139279
PMCPMC11319908

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