Evidence map›Paper›PMID 39139265›Full record

ArticlePNAS nexus2024

Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights.

Anshu Saran, Hey-Min Kim, Ireland Manning, Mark A Hancock, Claus Schmitz, Mariusz Madej, Jan Potempa, Maria Sola, Jean-François Trempe, Yongtao Zhu and 2 more

Abstract read
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Advances in the type IX secretion system: an exploration focusing onCurrent research in microbial sciences · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Anshu SaranDepartment of Anatomy and Cell Biology, McGill University, 3640 Rue University, Montreal, QC H3A 0C7, Canada.ORCID https://orcid.org/0000-0002-1232-4825
Hey-Min KimDepartment of Microbiology, The Forsyth Institute, 245 First St, Cambridge, MA 02142, USA.
Ireland ManningDepartment of Biological Sciences, Minnesota State University Mankato, 242 Trafton Science Center South, Mankato, MN 56001, USA.
Mark A HancockCentre de Recherche en Biologie Structurale (CRBS), McGill University, 3649 Promenade Sir William Olser, Montreal, QC H3G 0B1, Canada.ORCID https://orcid.org/0000-0001-7427-7449
Claus SchmitzDepartment of Structural Biology, Molecular Biology Institute of Barcelona, Spanish Research Council, Barcelona Science Park, Barcelona E-08028, Spain.ORCID https://orcid.org/0000-0003-0797-5508
Mariusz MadejDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, Kraków PL-30-387, Poland.ORCID https://orcid.org/0000-0002-9935-3871
Jan PotempaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, Kraków PL-30-387, Poland.ORCID https://orcid.org/0000-0002-3600-7461
Maria SolaDepartment of Structural Biology, Molecular Biology Institute of Barcelona, Spanish Research Council, Barcelona Science Park, Barcelona E-08028, Spain.ORCID https://orcid.org/0000-0002-0838-9706
Jean-François TrempeCentre de Recherche en Biologie Structurale (CRBS), McGill University, 3649 Promenade Sir William Olser, Montreal, QC H3G 0B1, Canada.ORCID https://orcid.org/0000-0002-6543-3371
Yongtao ZhuDepartment of Biological Sciences, Minnesota State University Mankato, 242 Trafton Science Center South, Mankato, MN 56001, USA.ORCID https://orcid.org/0000-0002-3069-6518
Mary Ellen DaveyDepartment of Microbiology, The Forsyth Institute, 245 First St, Cambridge, MA 02142, USA.ORCID https://orcid.org/0000-0001-8129-0537
Natalie ZeytuniDepartment of Anatomy and Cell Biology, McGill University, 3640 Rue University, Montreal, QC H3A 0C7, Canada.ORCID https://orcid.org/0000-0002-5708-4095

Funding

L-Arg Availability Affects the Physiological State of Porphyromonas gingivalisR01DE024580 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN · 2015 to 2024
$3.5M
NIDCR NIH HHS R01 DE024580
6 · The paper itself

Abstract

The type IX secretion system (T9SS) is a nanomachinery utilized by bacterial pathogens to facilitate infection. The system is regulated by a signaling cascade serving as its activation switch. A pivotal member in this cascade, the response regulator protein PorX, represents a promising drug target to prevent the secretion of virulence factors. Here, we provide a comprehensive characterization of PorX both

Indexed as

alkaline phosphatasebacterial pathogenicityPorphyromonas gingivalisresponse regulatortype IX secretion system

Identifiers

PMID39139265
PMCPMC11320123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.