Evidence map›Paper›PMID 39139090›Full record

ArticleGenesis (New York, N.Y. : 2000)2024

Generation of an Armcx1 Conditional Knockout Mouse.

Cora L Bright, Howard M Bomze, Mantu Bhaumik, Jeremy N Kay, Romain Cartoni, Sidney M Gospe

Abstract read
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. HomozygousTranslational andrology and urology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cora L BrightUniversity Program in Genetics and Genomics, Duke University Graduate School, Durham, North Carolina, USA.ORCID 0000-0001-8683-0475
Howard M BomzeDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
Mantu BhaumikDepartment of Neurology, F.M. Kirby Neurobiology Center, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, USA.
Jeremy N KayDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
Romain CartoniDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
Sidney M GospeDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-2838-7983

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Regulation of the retinal ganglion cell repair program by the mitochondrial protein Armcx1R01EY030969 · NEI · DUKE UNIVERSITY · PI Sidney M Gospe · 2022 to 2026
$2.0M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY030969NICHD NIH HHS P50 HD105351NIH HHS CoreGrantEY005722NIH HHS P50 HD105351NIH HHS R01EY030969Research to Prevent Blindness
6 · The paper itself

Abstract

Armadillo repeat-containing X-linked protein-1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote retinal ganglion cell (RGC) survival and axonal regrowth in a mouse optic nerve crush model. In order to evaluate the functions of endogenous Armcx1 in vivo, we have created a conditional Armcx1 knockout mouse line in which the entire coding region of the Armcx1 gene is flanked by loxP sites. This Armcx1

Indexed as

Armadillo Domain ProteinsRetinal Ganglion CellsAnimalsMiceMice, KnockoutOptic NerveRetinaArmadillo Domain Proteinsarmadillo repeat‐containing X‐linked protein‐1conditional knockoutmitochondriaretinal ganglion cell

Identifiers

PMID39139090
PMCPMC11364276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.