ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Standardized statistical framework for comparison of biomarkers: Techniques from ADNI.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer's disease.BMC medicine · 2026Article
- Multi-modal proton and sodium MRI for outcome prediction in mild traumatic brain injury.Journal of neurology · 2025Article
- Domain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.Heliyon · 2025Article
- Standardized statistical framework for comparison of biomarkers: Techniques from ADNI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Contributions of the ADNI Biostatistics Core.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- A clinical perspective on the revised criteria for diagnosis and staging of Alzheimer's disease.Nature aging · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionWell-chosen biomarkers have the potential to increase the efficiency of clinical trials and drug discovery and should show good precision as well as clinical validity.
methodsWe suggest measures that operationalize these criteria and describe a general approach that can be used for inference-based comparisons of biomarker performance. The methods are applied to measures obtained from structural magnetic resonance imaging (MRI) from individuals with mild dementia (n = 70) or mild cognitive impairment (MCI; n = 303) enrolled in the Alzheimer's Disease Neuroimaging Initiative.
resultsVentricular volume and hippocampal volume showed the best precision in detecting change over time in both individuals with MCI and with dementia. Differences in clinical validity varied by group. DISCUSSION: The methodology presented provides a standardized framework for comparison of biomarkers across modalities and across different methods used to generate similar measures and will help in the search for the most promising biomarkers. HIGHLIGHTS: A framework for comparison of biomarkers on pre-defined criteria is presented. Criteria for comparison include precision in capturing change and clinical validity. Ventricular volume has high precision in change for both dementia and mild cognitive impairment (MCI) trials. Imaging measures' performance in clinical validity varies more for dementia than for MCI.
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