ArticleJournal of medical ultrasonics (2001)2025
Usefulness of color Doppler and strain elastography adjunctive to B-mode ultrasonography in the diagnosis of non-mass abnormalities of the breast: results of the BC-07 multicenter study of 385 cases.
Article in Journal of medical ultrasonics (2001), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Colour maps for representation of quantitative metrics in radiology: meaningful or misleading?Insights into imaging · 2026Review
- Multimodal Deep Learning-Based Classification of Breast Non-Mass Lesions Using Gray Scale and Color Doppler Ultrasound.Diagnostics (Basel, Switzerland) · 2025Article
- Ductal abnormalities as primary findings on breast ultrasonography: a literature review and proposed classification.Ultrasonography (Seoul, Korea) · 2025Article
- The value of intratumoral and peritumoral ultrasound radiomics model constructed using multiple machine learning algorithms for non-mass breast cancer.Scientific reports · 2025Article
- Diagnostic efficacy of multimodal imaging in non-mass-like breast lesions and correlation with pathological findings.Frontiers in oncology · 2025Article
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10 authors.
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Abstract
purposeThe concept of non-mass abnormalities of the breast has been employed in Japan for approximately 20 years. Although B-mode findings are classified as non-mass abnormalities, the usefulness of adding color Doppler ultrasonography (US) and strain elastography to B-mode US is unclear. Therefore, we conducted a multicenter study (JABTS BC-07) to establish the diagnostic criteria for breast US, including color Doppler and elastography, for non-mass abnormalities of the breast and verify their diagnostic usefulness.
methodsWe registered US images of non-mass abnormalities of the breast and their clinical and histopathological data from 13 institutions (202 malignant and 183 benign non-mass lesions). Furthermore, we evaluated the centralized image interpretation usefulness of the diagnostic criteria for B-mode and color Doppler US, as well as the sensitivity and specificity when color Doppler US and elastography were added to B-mode US.
resultsEchogenic foci in the mammary gland (odds ratio 3.45, 95% confidence interval [CI] 1.92-6.19, p < 0.0001) and the configuration of internal solid components of the ducts (odds ratio 0.056, 95% CI 0.005-0.591, p < 0.0165) significantly differentiated benign and malignant non-mass abnormalities. The sensitivity of B-mode alone (83.7%) was significantly improved by adding color Doppler US (93.1%) (p = 0.0004); however, adding color Doppler US and elastography to B-mode US made no significant difference in either sensitivity or specificity.
conclusionAlthough adding color Doppler US and elastography to B-mode US improved sensitivity, the diagnostic significance was limited. Therefore, a comprehensive diagnostic method comprising mammography and magnetic resonance imaging is warranted.
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