Evidence map›Paper›PMID 39138574›Full record

ArticleGenome medicine2024

Laterality, heterotaxy, and isolated congenital heart defects : The genetic basis of the segmental nature of the heart.

Carolina Putotto, Flaminia Pugnaloni, Marta Unolt, Giulio Calcagni, Paolo Versacci, Bruno Marino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolina PutottoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy. carolina.putotto@uniroma1.it.
Flaminia PugnaloniFetal, Neonatal, and Cardiological Sciences Research Area, Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, 00146, Italy.
Marta UnoltFetal, Neonatal, and Cardiological Sciences Research Area, Pediatric Cardiology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, 00146, Italy.
Giulio CalcagniFetal, Neonatal, and Cardiological Sciences Research Area, Pediatric Cardiology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, 00146, Italy.
Paolo VersacciDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.
Bruno MarinoDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, the role of NODAL in normal and abnormal L-R asymmetry has been well established. In a recent paper, mutations of this gene have been reported in heterotaxy but also in transposition with D- or L-ventricular loop. The effects of NODAL and other laterality genes can be recognized separately in all three cardiac segments: for topology and septation of the atria, for ventricular looping, and for spiralization and alignment of the great arteries.

Indexed as

Heart Defects, CongenitalHeterotaxy SyndromeAnimalsHeartHumansMutationNodal ProteinNodal ProteinCongenital heart diseaseHeterotaxyLaterality defectsLaterality genesNodal

Identifiers

PMID39138574
PMCPMC11323548

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.