Evidence map›Paper›PMID 39138542›Full record

ArticleBMC research notes2024

High serum levels of reactive nitrogen species and low total antioxidant capacity in patients with resistant hypertension compared to those in age- gender matched healthy controls, controlled hypertension and follow up with propranolol treatment in the extended APPROPRIATE trial.

H N Ranasinghe, P N Weeratunga, N Fernando, P Katulanda, S Rajapakse, P Galappatthy, S M Handunnetti, G R Constantine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

H N RanasingheDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. harshaninr@yahoo.com.
P N WeeratungaDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
N FernandoInstitute of Biochemistry, Molecular Biology & Biotechnology, University of Colombo, Colombo, Sri Lanka.
P KatulandaDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
S RajapakseDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
P GalappatthyDepartment of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
S M HandunnettiInstitute of Biochemistry, Molecular Biology & Biotechnology, University of Colombo, Colombo, Sri Lanka.
G R ConstantineDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo perform a comparative analysis of the extended APPROPRIATE trial of measures of reactive nitrogen species and antioxidant capacity in patients having resistant hypertension with controlled hypertension and healthy controls.

resultsMean serum NO

Indexed as

Antihypertensive AgentsAntioxidantsHypertensionPropranololReactive Nitrogen SpeciesAdultAgedBlood PressureCase-Control StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedAntihypertensive AgentsAntioxidantsPropranololReactive Nitrogen SpeciesAnti-oxidant capacityOxidative stressReactive nitrogen speciesResistant hypertension, Sri Lanka

Identifiers

PMID39138542
PMCPMC11323664

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.