Evidence map›Paper›PMID 39138494›Full record

ArticleEnvironmental health : a global access science source2024

Urinary polycyclic aromatic hydrocarbon metabolites and their association with oxidative stress among pregnant women in Los Angeles.

Qi Meng, Sanjali Mitra, Irish Del Rosario, Michael Jerrett, Carla Janzen, Sherin U Devaskar, Beate Ritz

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PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Qi MengDepartment of Epidemiology, University of California, Los Angeles, CA, 90095, USA.
Sanjali MitraDepartment of Epidemiology, University of California, Los Angeles, CA, 90095, USA.
Irish Del RosarioDepartment of Epidemiology, University of California, Los Angeles, CA, 90095, USA.
Michael JerrettDepartment of Environmental Health Sciences, University of California, Los Angeles, CA, 90095, USA.
Carla JanzenDepartment of Obstetrics & Gynecology, University of California, Los Angeles, CA, 90095, USA.
Sherin U DevaskarDepartment of Pediatrics, University of California, Los Angeles, CA, 90095, USA.
Beate RitzDepartment of Epidemiology, University of California, Los Angeles, CA, 90095, USA. britz@ucla.edu.

Funding

Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TEITELBAUM, SUSAN L · 2015 to 2025
$26.4M
National Exposure Assessment Laboratory at EmoryU2CES026560 · NIEHS · EMORY UNIVERSITY · PI WALLER, LANCE A · 2015 to 2015
$8.3M
Imaging Innovations for Placental Assessment in Response to Environmental PollutionU01HD087221 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U, JANZEN, CARLA · 2015 to 2015
$4.3M
California Air Resources Board 17RD012National Institute of Child Health and Human Development U01HD087221NICHD NIH HHS U01 HD087221NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026560
6 · The paper itself

Abstract

backgroundPolycyclic aromatic hydrocarbons (PAHs) have been linked to adverse birth outcomes that have been reported to be induced by oxidative stress, but few epidemiological studies to date have evaluated associations between urinary PAH metabolites and oxidative stress biomarkers in pregnancy and identified critical periods for these outcomes and PAH exposures in pregnancy.

methodsA cohort of pregnant women was recruited early in pregnancy from antenatal clinics at the University of California Los Angeles during 2016-2019. We collected urine samples up to three times during pregnancy in a total of 159 women enrolled in the cohort. A total of 7 PAH metabolites and 2 oxidative stress biomarkers [malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG)] were measured in all available urine samples. Using multiple linear regression models, we estimated the percentage change (%) and 95% confidence interval (CI) in 8-OHdG and MDA measured at each sample collection time per doubling of PAH metabolite concentrations. Furthermore, we used linear mixed models with a random intercept for participant to estimate the associations between PAH metabolite and oxidative stress biomarker concentrations across multiple time points in pregnancy.

resultsMost PAH metabolites were positively associated with both urinary oxidative stress biomarkers, MDA and 8-OHdG, with stronger associations in early and late pregnancy. A doubling of each urinary PAH metabolite concentration increased MDA concentrations by 5.8-41.1% and 8-OHdG concentrations by 13.8-49.7%. Linear mixed model results were consistent with those from linear regression models for each gestational sampling period.

conclusionUrinary PAH metabolites are associated with increases in oxidative stress biomarkers during pregnancy, especially in early and late pregnancy.

Indexed as

BiomarkersOxidative StressPolycyclic Aromatic Hydrocarbons8-Hydroxy-2'-DeoxyguanosineAdultCohort StudiesEnvironmental PollutantsFemaleHumansLos AngelesMalondialdehydeMaternal ExposurePregnancyYoung Adult8-Hydroxy-2'-DeoxyguanosineBiomarkersEnvironmental PollutantsMalondialdehydePolycyclic Aromatic HydrocarbonsOxidative stressPAH (polycyclic aromatic hydrocarbons)Pregnancy

Identifiers

PMID39138494
PMCPMC11321171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.